Search Results
Overview
| Uniprot ID | A0A4X1WA58 |
|---|---|
| Protein Name | Actin-related protein 2 |
| Gene Name | ACTR2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 111 | NIDTRNCKILLTEPP |
| 224 | TVRMIKEKLCYVGYN |
| 258 | LPDGRIIKVGGERFE |
| 327 | SRLERELKQLYLERV |
| 336 | LYLERVLKGDVEKLS |
| 341 | VLKGDVEKLSKFKIR |
| 373 | LADIMKDKDNFWMTR |
| 386 | TRQEYQEKGVRVLEK |
| 393 | KGVRVLEKLGVTVR* |
| 46 | PIIRSTTKVGNIEIK |
| 7 | *MDSQGRKVVVCDNG |
Function
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament
Protein Sequence
10
MDSQGRKVVV
20
CDNGTGFVKC
30
GYAGSNFPEH
40
IFPALVGRPI
50
IRSTTKVGNI
60
EIKNNKKMDL
70
MVGDEASELR
80
SMLEVNYPME
90
NGIVRNWDDM
100
KHLWDYTFGP
110
EKLNIDTRNC
120
KILLTEPPMN
130
PTKNREKIVE
140
VMFETYQFSG
150
VYVAIQAVLT
160
LYAQGLLTGV
170
VVDSGDGVTH
180
ICPVYEGFSL
190
PHLTRRLDIA
200
GRDITRYLIK
210
LLLLRGYAFN
220
HSADFETVRM
230
IKEKLCYVGY
240
NIEQEQKLAL
250
ETTVLVESYT
260
LPDGRIIKVG
270
GERFEAPEAL
280
FQPHLINVEG
290
VGVAELLFNT
300
IQAADIDTRS
310
EFYKHIVLSG
320
GSTMYPGLPS
330
RLERELKQLY
340
LERVLKGDVE
350
KLSKFKIRIE
360
DPPRRKHMVF
370
LGGAVLADIM
380
KDKDNFWMTR
390
QEYQEKGVRV
LEKLGVTVR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005885 | Arp2/3 protein complex |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0005524 | ATP binding |
| Biological Process | GO:0034314 | Arp2/3 complex-mediated actin nucleation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.