Search Results
Overview
| Uniprot ID | A0A4X1WBI1 |
|---|---|
| Protein Name | Keratin, type II cytoskeletal 8 |
| Gene Name | KRT8 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 11 | RVTQKSYKVSTSGPR |
| 116 | KFASFIDKVRHLEQQ |
Function
Required for the formation of KRT8/KRT18 filaments that are involved in ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement. Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle
Protein Sequence
10
MSIRVTQKSY
20
KVSTSGPRSF
30
SSRSYTSGPG
40
TRISSSAFSR
50
VGSSSSSFRG
60
GLGSGMSLVG
70
GYGGPSGLGG
80
ITAVTVNQSL
90
LSPLKLEVDP
100
NIQAVRTQEK
110
EQIKTLNNKF
120
ASFIDKVRHL
130
EQQNKVLETK
140
WNLLQQQKTA
150
RSNIDNMFES
160
YINNLRRQLE
170
TLAQEKLKLE
180
VELGNMQGLV
190
EDFKNKYEEE
200
IQKRTDMENE
210
FVIIKKDVDE
220
AYMNKVELES
230
RLEGLTDEIN
240
FYRQLYEEEI
250
REMQSQISDT
260
SVVLSMDNSR
270
SLDLDGIIAE
280
VKAQYEEIAN
290
RSRAEAETMY
300
QIKYEELQSL
310
AGKHGDDLRR
320
TKTEISEMNR
330
NISRLQAEIE
340
GLKGQRASLE
350
AAIADAEQRG
360
ELAVKDAQAK
370
LAELEAALRT
380
AKQDMARQLR
390
EYQELMNVKL
400
ALDVEIATYR
410
KLLEGEESRL
420
ESGMQNMSIH
430
TKTTSGYSGG
440
VTYGTPGFNY
450
SLSSYQSGGL
460
GSVGGSGSFS
470
RTSSKAVVVK
480
KIETRDGKLV
SESSDVLSK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016327 | apicolateral plasma membrane |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0045095 | keratin filament |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Biological Process | GO:0045214 | sarcomere organization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.