Search Results
Overview
| Uniprot ID | A0A4X1WCL6 |
|---|---|
| Protein Name | Malate dehydrogenase |
| Gene Name | MDH1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 108 | MERKDLLKANVKIFK |
| 112 | DLLKANVKIFKCQGA |
| 115 | KANVKIFKCQGAALD |
| 123 | CQGAALDKYAKKSVK |
| 130 | KYAKKSVKVIVVGNP |
| 147 | TNCLTASKSAPSIPK |
| 154 | KSAPSIPKENFSCLT |
| 169 | RLDHNRAKAQIALKL |
| 204 | YPDVNHAKVKLQAKE |
| 210 | AKVKLQAKEVGVYEA |
| 241 | QRGAAVIKARKLSSA |
| 244 | AAVIKARKLSSAMSA |
| 253 | SSAMSAAKAICDHVR |
Function
Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS)
Protein Sequence
10
MLNIFSSEPI
20
RVLVTGAAGQ
30
IAYSLLYSIG
40
NGSVFGKDQP
50
IILVLLDITP
60
MMGVLDGVLM
70
ELQDCALPLL
80
KDVIATDKEE
90
IAFKDLDVAI
100
LVGSMPRRDG
110
MERKDLLKAN
120
VKIFKCQGAA
130
LDKYAKKSVK
140
VIVVGNPANT
150
NCLTASKSAP
160
SIPKENFSCL
170
TRLDHNRAKA
180
QIALKLGVTS
190
DDVKNVIIWG
200
NHSSTQYPDV
210
NHAKVKLQAK
220
EVGVYEAVKD
230
DSWLKGEFIT
240
TVQQRGAAVI
250
KARKLSSAMS
260
AAKAICDHVR
270
DIWFGTPEGE
280
FVSMGIISDG
290
NSYGVPDDLL
300
YSFPVTIKDK
310
TWKIVEGLPI
320
NDFSREKMDL
330
TAKELAEEKE
TAFEFLSSA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0030060 | L-malate dehydrogenase (NAD+) activity |
| Biological Process | GO:0006108 | malate metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.