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Overview

Uniprot IDA0A4X1WDK2
Protein NamePhospholipase A-2-activating protein
Gene NamePLAA
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
259 DRSLRIWKHGECAQT
647 FCNCFVGKAGQKLMM
751 GVDSQIKKFASVSEP

Function

Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis

Protein Sequence

10 MASGATRYRL 20 SCSLPGHELD 30 VRGLVCCLYP 40 PGAFVSVSRD 50 RTTRLWVPDS 60 PNRGFTEMHC 70 MSGHSNFVSC 80 VCIIPSSDMY 90 PHGLIATGGN 100 DHNICIFSLE 110 SPAPLYVLKG 120 HKNTVCSLSS 130 GKFGTLLSGS 140 WDTTAKVWLN 150 DKCMMTLQGH 160 TAAVWAVKIL 170 PEQGLMLTGS 180 ADKTIKLWKA 190 GRCERTFSGH 200 EDCVRGLAIL 210 SETEFLSCAN 220 DASIRKWQIT 230 GECLEVFYGH 240 TNYIYSISVF 250 PNCKDFVTTG 260 EDRSLRIWKH 270 GECAQTIRLP 280 AQSIWCCCVL 290 NNGDIVVGAS 300 DGIIRVFTES 310 EDRTANAEEI 320 KAFERELSQA 330 TIDSKTGDLG 340 DINAEQLPGR 350 EHLNEPGTRE 360 GQTRLIRDGE 370 KVEAYQWSVS 380 ERRWIKIGDV 390 VGSSGANQQT 400 SGKVLYEGKE 410 FDYVFSIDVN 420 EGGPSYKLPY 430 NISDDPWLTA 440 YNFLQKNDLN 450 PMFLDQVAKF 460 IIDNTQGQML 470 GLGNTNFSDP 480 FTGGGRYVPG 490 SANMGTMMAG 500 VDPFTGNSAY 510 QSAASKTVNI 520 YFPKKEAVTF 530 DQANPTQILG 540 KLKELNGTAS 550 EDKKLTEEDL 560 VLLEKILSLI 570 CNNSSEKPTA 580 QQLQTLWKAV 590 NWPEDIVFPA 600 LDILRLSIKH 610 PSVNENFCNE 620 KEGTQFSSHL 630 INLLNPKGKP 640 ANQLLALRTF 650 CNCFVGKAGQ 660 KLMMSQRESL 670 MSQAIELKSG 680 SNKNIHIALA 690 TLTLNYSVCF 700 HKDHNIEGKA 710 QCLSVISTVL 720 EVVQDLEATF 730 RLLVALGTLI 740 SDDSNAVQLA 750 KSLGVDSQIK 760 KFASVSEPAK 770 VSECCRLILN LL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0045202 synapse
Molecular Function GO:0016005 phospholipase A2 activator activity
Biological Process GO:0007399 nervous system development

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.