Overview
| Uniprot ID | A0A5G2Q6W7 |
|---|
| Protein Name | Intercellular adhesion molecule 1 |
|---|
| Gene Name | ICAM1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 424 |
ARGNPTPKLICRREG |
Function
Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1
Protein Sequence
10
HTLCSSHPAS
20
GPLHLLLFGL
30
GGAEISMWPL
40
NTIIPKGGSM
50
KVNCSVACDG
60
NITSFGLETH
70
WHKTEVDHRD
80
KWKIFELSNV
90
ENDGTLLCHA
100
VCQGNQTQVQ
110
GNLTVYWFPE
120
YVKLANLSWQ
130
REGQHFNLSC
140
QVSGGAPRTN
150
LSAVLFRGEE
160
ELFRQSVGME
170
EPANVTFRML
180
ASRKDHGANF
190
SCRTELNLQP
200
QGLELFWNSS
210
APLKLQTYVL
220
PATHPHLATP
230
ELVEVGTPVS
240
VNCSLDGLFP
250
ASEATVHLAR
260
GDHRPPLTIT
270
HNGDSLLAKT
280
WINGTEKEQG
290
TQYLVCEIML
300
ADEKVVTKKN
310
VTFYSFPPPN
320
LTLSEPEVSE
330
GTTVSIECQA
340
HGEAVVTLNE
350
VPAETPSQRA
360
QLKLNVSAED
370
HGRSFSCSAA
380
LTVAGHVLYK
390
NQTQVLSVLY
400
GPRLDERDCP
410
GNWTWPEGSH
420
QTLTCQARGN
430
PTPKLICRRE
440
GDGALLPTGD
450
LGPVKREITG
460
TYQCQATSSR
470
GVATRVVVVN
480
VIHNQNNMVI
490
IIPVAAVAIL
500
GSVGVAAYIY
510
NYQRKIQKYE
520
LQKAQENAAM
KLSTPASPP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016020 |
membrane |
| Molecular Function |
GO:0005178 |
integrin binding |
| Biological Process |
GO:1901701 |
cellular response to oxygen-containing compound |
| Biological Process |
GO:0002252 |
immune effector process |
| Biological Process |
GO:0006955 |
immune response |
| Biological Process |
GO:0007159 |
leukocyte cell-cell adhesion |
| Biological Process |
GO:0050900 |
leukocyte migration |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.