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Overview

Uniprot IDA0A5G2Q7C7
Protein NameLow-density lipoprotein receptor
Gene NameLDLR
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
222 CEGPNKFKCQSGECI

Function

Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization

Protein Sequence

10 MSVTCKIGDF 20 SCGGRVNRCI 30 PESWRCDGQQ 40 DCENGSDEEG 50 CSPKTCSQDE 60 FRCQDGKCIA 70 PKFVCDSDRD 80 CLDGSDEASC 90 PTPTCGPASF 100 QCNSSTCIPE 110 LWACDGDPDC 120 EDGSDEWPQH 130 CRSHSSSLPE 140 RSNNPCSALE 150 FHCHSGECIH 160 SSWRCDGDTD 170 CKDKSDEENC 180 DVATCRPDEF 190 QCSDGTCIHG 200 SRQCDREYDC 210 KDLSDEQGCV 220 NVTLCEGPNK 230 FKCQSGECIS 240 LDKVCNSVRD 250 CRDWSDEPLK 260 ECGTNECLDN 270 KGGCSHICND 280 LKIGYECLCP 290 EGFQLVDKHR 300 CEDIDECQDP 310 DACSQICVNL 320 EGSYKCQCEE 330 GFQLEPLTKA 340 CKAIGTIAYL 350 FFTNRHEVRK 360 MTLDRSEYTS 370 LIPNLKNVVA 380 LDTEVASNRI 390 YWSDLSQRKI 400 YSTQINRAPS 410 FSSYDTIIGE 420 DLQAPDGLAV 430 DWIHSNIYWT 440 DSILGTVSVA 450 DTKGVKRKTL 460 FQEKGSKPRA 470 IVVDPVHGFM 480 YWTDWGTPAK 490 IKKGGLNGVD 500 VYSLVTEDIQ 510 WPNGITLDLS 520 GGRLYWVDSK 530 LHSISSIDVN 540 GGNRKTVLED 550 KTKLAHPFSL 560 AIFEDKVFWT 570 DVINEAIFSA 580 NRLTGSDIHL 590 MAENLLSPED 600 IVLFHNLTQP 610 RGVNWCERTA 620 LQNGGCQYLC 630 LPAPQINPRS 640 PKFTCACPDG 650 MLLAKDMRSC 660 LTETEPAGTT 670 QGPSMVNSTA 680 VGPKHTASSE 690 LTTAESVTMS 700 QHALGDVAGR 710 GVTEKPQSVG 720 ALYIVLPIAL 730 LILLFFGTFL 740 LWKNWRLKSI 750 NSINFDNPVY 760 QKTTEDEVHI 770 CRSQDGYTYP 780 SRQMVSLEDD VA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0005769 early endosome
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005770 late endosome
Cellular Component GO:0034362 low-density lipoprotein particle
Cellular Component GO:0005764 lysosome
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005509 calcium ion binding
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0006897 endocytosis
Biological Process GO:0006869 lipid transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.