Search Results

Overview

Uniprot ID	A0A5G2Q7D7
Protein Name	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Gene Name	SDHA
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
152	FSRTEDGKIYQRAFG
164	AFGGQSLKFGKGGQA
523	VLQEGCEKILRLYGD
593	VDEYDYSKPIQGQQK
601	PIQGQQKKPFQEHWR
609	PFQEHWRKHTLSYVD
618	TLSYVDVKTGKVSLE
621	YVDVKTGKVSLEYRP

Function

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate. Can act as a tumor suppressor

Protein Sequence

10 PERAFQQPAA 20 SPIGARSFHF 30 TVDGNKRSSA 40 KVSDAISTQY 50 PVVDHEFDAV 60 VVGAGGAGLR 70 AAFGLSEAGF 80 NTACVTKLFP 90 TRSHTVAAQG 100 GINAALGNME 110 EDNWRWHFYD 120 TVKGSDWLGD 130 QDAIHYMTEQ 140 APASVVELEN 150 YGMPFSRTED 160 GKIYQRAFGG 170 QSLKFGKGGQ 180 AHRCCCVADR 190 TGHSLLHTLY 200 GRSLRYDTSY 210 FVEYFALDLL 220 MENGECRGVI 230 ALCIEDGSIH 240 RIRARNTVVA 250 TGGYGRTYFS 260 CTSAHTSTGD 270 GTAMVTRAGL 280 PCQDLEFVQF 290 HPTGIYGAGC 300 LITEGCRGEG 310 GILINSQGER 320 FMERYAPVAK 330 DLASRDVVSR 340 SMTLEIREGR 350 GCGPEKDHVY 360 LQLHHLPPEQ 370 LAVRLPGISE 380 TAMIFAGVDV 390 TKEPIPVLPT 400 VHYNMGGIPT 410 NYKGQVLRHV 420 NGQDQVVPGL 430 YACGEAACAS 440 VHGANRLGAN 450 SLLDLVVFGR 460 ACALSIAESC 470 RPGDKVPSIK 480 PNAGEESVMN 490 LDKLRFANGT 500 IRTSELRLSM 510 QKSMQSHAAV 520 FRVGSVLQEG 530 CEKILRLYGD 540 LQHLKTFDRG 550 MVWNTDLVET 560 LELQNLMLCA 570 LQTIYGAEAR 580 KESRGAHARE 590 DFKERVDEYD 600 YSKPIQGQQK 610 KPFQEHWRKH 620 TLSYVDVKTG 630 KVSLEYRPVI 640 DKTLNEADCA TVPPAIRSY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Molecular Function	GO:0050660	flavin adenine dinucleotide binding
Molecular Function	GO:0008177	succinate dehydrogenase (quinone) activity
Biological Process	GO:0022900	electron transport chain
Biological Process	GO:0006099	tricarboxylic acid cycle

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.