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Overview

Uniprot IDA0A5G2Q7I1
Protein NameDNA replication licensing factor MCM2
Gene NameMCM2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
236 GHGHNVFKERISDMC
404 RIQESPGKVAAGRLP
470 HVAKKDNKVAVGELT
512 IYGHEDIKRGLALAL
554 TAKSQFLKYIEKVSS
558 QFLKYIEKVSSRAIF

Function

Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis

Protein Sequence

10 MQKEARRSQV 20 FGPIFSSPPP 30 QESSESFTVA 40 SSPAPRRRGS 50 DPLTSSPGRS 60 SRRTDALTSS 70 PGRDLPPFED 80 ESEGLLGTEG 90 PLEEEEEDGE 100 ELIGDGMERD 110 YRAIPELDVY 120 EPEGLALDDE 130 DVEELTASQR 140 EAAERAMRQR 150 DREAGRGLGR 160 MRRGLLYDSD 170 EEEEERPSRK 180 RRQVERATED 190 GEEDEEMIES 200 IENLEDLKGH 210 SVREWVSMAG 220 PRLEIHHRFK 230 NFLRTHVDGH 240 GHNVFKERIS 250 DMCKENRESL 260 VVNYEDLAAR 270 EHVLAYFLPE 280 APAELLQIFD 290 EAALEVVLAM 300 YPKYDRIASH 310 IHVRISHLPL 320 VEELRSLRQL 330 HLNQLIRTSG 340 VVTSCTGVLP 350 QLSMVKYNCN 360 KCGFVLGPFC 370 QSQNQEVKPG 380 SCPECQSAGP 390 FEVNMEETIY 400 QNYQRIRIQE 410 SPGKVAAGRL 420 PRSKDAILLA 430 DLVDSCKPGD 440 EIELTGIYHN 450 NYDGALNTAN 460 GFPVFATVIL 470 ANHVAKKDNK 480 VAVGELTDED 490 VKMITSLSKD 500 QQIGEKIFAS 510 IAPSIYGHED 520 IKRGLALALF 530 GGEPKNPGGK 540 HKVRGDINVL 550 LCGDPGTAKS 560 QFLKYIEKVS 570 SRAIFTTGQG 580 ASAVGLTAYV 590 QRHPVSREWT 600 LEAGALVLAD 610 RGVCLIDEFD 620 KMNDQDRTSI 630 HEAMEQQSIS 640 ISKAGIVTSL 650 QARCTVIAAA 660 NPIGGRYDPS 670 LTFSENVDLT 680 EPIISRFDIL 690 CVVRDTVDPV 700 QDEMLARFVV 710 GSHVRHHPSN 720 KEDGGLGGTP 730 EPAMPNTYGV 740 EPLPQEVLRK 750 YIIYAKEKVH 760 PKLNQMDQDK 770 VAKMYSDLRK 780 ESMATGSIPI 790 TVRHIESMIR 800 MAEAHARIHL 810 RDYVMEDDVN 820 MAIRVMLESF 830 VDTQKFSVMR 840 SMRKTFARYL 850 SFRRDNNELL 860 LFILKQLVAE 870 QVAYQRSRFG 880 AQQDTIEVPE 890 KDLVDKARQI 900 NIHNLSAFYD 910 SELFRMNKFS 920 HDLKRKVILQ QF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0042555 MCM complex
Cellular Component GO:0005664 nuclear origin of replication recognition complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003678 DNA helicase activity
Molecular Function GO:0003688 DNA replication origin binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0003697 single-stranded DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006915 apoptotic process
Biological Process GO:0090102 cochlea development
Biological Process GO:0000727 double-strand break repair via break-induced replication
Biological Process GO:1902975 mitotic DNA replication initiation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.