Search Results

Overview

Uniprot IDA0A5G2Q8V3
Protein NameEndoplasmic reticulum transmembrane helix translocase
Gene NameATP13A1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
778 CPLKADSKAVIREIQ

Function

Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum. Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane. Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains

Protein Sequence

10 MAAAVGNAVP 20 CGARHCGARP 30 AGQPKPKPQP 40 RTVLAAGPAL 50 IASGDELVAA 60 VWPYRRLALL 70 RRLTVLPFAG 80 LLYPAWLGAA 90 AAGCWGWGSS 100 WAQIPEAALL 110 VLATICLAHA 120 LTVLSGHWSV 130 HAHCALTCTP 140 EYDPSKATFV 150 KVVPTPNNGS 160 TELVALHRDE 170 GEDGQEVLSF 180 EFQKIKYSYD 190 ALEKKRFLPV 200 AFPVGNAFSY 210 YQSNRGFQED 220 SEIRAAEKKF 230 GSNKAEMVVP 240 DFSELFKERA 250 TAPFFVFQVF 260 CVGLWCLDEY 270 WYYSVFTLSM 280 LVAFEASLVQ 290 QQMRNMSEIR 300 KMGNKPHMIQ 310 VYRSRKWRPI 320 ASDEVVPGDI 330 VSIGRSPQEN 340 LVPCDVLLLR 350 GRCIVDEAML 360 TGESVPQMKE 370 PIEDLSPNRV 380 LDLQADSRLH 390 VIFGGTKVVQ 400 HIPPQKATTG 410 LKPVDNGCVA 420 FVLRTGFNTS 430 QGKLLRTILF 440 GVKRVTANNL 450 ETFIFILFLL 460 VFAIAAAAYV 470 WIEGTKDPSR 480 NRYKLFLECT 490 LILTSVVPPE 500 LPIELSLAVN 510 TSLIALAKLY 520 MYCTEPFRIP 530 FAGKVEVCCF 540 DKTGTLTSDS 550 LVVRGVAGLR 560 DGKEVTPVSN 570 IPIETHRALA 580 SCHSLMQLDD 590 GTLVGDPLEK 600 AMLTAVDWTL 610 TKDEKVFPRS 620 IKTQGLKIHQ 630 RFHFASALKR 640 MSVLASYEKL 650 GSTDLCYIAA 660 VKGAPETLHS 670 MFAQCPPDYH 680 HIHTEISREG 690 ARVLALGYKE 700 LGHLTHQQGC 710 TCRIWRFLGW 720 GSNQNCSCQP 730 TPQLQQHQIL 740 NPLSEAKDGT 750 CILMDASQAR 760 EVKREALECN 770 LKFVGFIVVS 780 CPLKADSKAV 790 IREIQNASHR 800 VVMITGDNPL 810 TACHVAQELH 820 FIEKAHTLIL 830 QPPTEKGQPC 840 EWRSIDGSII 850 LPLAPGSPKA 860 LALEHALCLT 870 GDGLAHLQAE 880 DPQLLLRLIP 890 YVQVFARVAP 900 KQKEFVITSL 910 KELGYVTLMC 920 GDGTNDVGAL 930 KHADVGVALL 940 ANAPERVIER 950 RRRPRDSPIL 960 SNSGVRTTSR 970 AAKQRSGLPP 980 PEEQLASQRD 990 RLSQVLRDLE 1000 DESTPIVKLG 1010 DASIAAPFTS 1020 KLSSIQCICH 1030 VIKQGRCTLV 1040 TTLQMFKILA 1050 LNALILAYSQ 1060 SVLYLEGVKF 1070 SDFQATLQGL 1080 LLAGCFLFIS 1090 RSKPLKTLSR 1100 ERPLPNIFNL 1110 YTILTVMLQF 1120 CVHFVSLVYL 1130 YSEAQARSPE 1140 KQEQFVDLYK 1150 EFEPSLVNST 1160 VYIMAMAMQM 1170 ATFAINYKGP 1180 PFMESLPENR 1190 PLVWSLAVSL 1200 FAIVGLLLGS 1210 SPDFNSQFGL 1220 VDIPVEFKLV 1230 IAQVLLLDFC 1240 LALLADRVLQ 1250 FFLGTPKLKV PS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
Molecular Function GO:0140567 membrane protein dislocase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0015662 P-type ion transporter activity
Biological Process GO:0140569 extraction of mislocalized protein from ER membrane
Biological Process GO:0006874 intracellular calcium ion homeostasis
Biological Process GO:0015031 protein transport
Biological Process GO:0055085 transmembrane transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.