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Overview

Uniprot IDA0A5G2Q9I2
Protein Name26S proteasome regulatory subunit 6A
Gene NamePSMC3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
130 DSEIKIMKSEVLRVT
199 KGKCAVIKTSTRQTY
247 TEYDSRVKAMEVDER
285 LPMNHKEKFENLGIQ
319 RACAAQTKATFLKLA
350 RDAFALAKEKAPSII

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides

Protein Sequence

10 MLSQVMGFRH 20 SRPDLPPSQS 30 PASPPRLCPG 40 GLPRQRARAE 50 LGRWQEPGAV 60 DTSCICSGEE 70 RGESPAQDGR 80 TGPEMNLLPQ 90 LESPVTRQEK 100 MATVWDEAEQ 110 DGIGEEVLKM 120 STEEIVQRTR 130 LLDSEIKIMK 140 SEVLRVTHEL 150 QAMKDKIKEN 160 SEKIKVNKTL 170 PYLVSNVIEL 180 LDVDPNDQEE 190 DGANIDLDSQ 200 RKGKCAVIKT 210 STRQTYFLPV 220 IGLVDAEKLK 230 PGDLVGVNKD 240 SYLILETLPT 250 EYDSRVKAME 260 VDERPTEQYS 270 DIGGLDKQIQ 280 ELVEAIVLPM 290 NHKEKFENLG 300 IQPPKGVLMY 310 GPPGTGKTLL 320 ARACAAQTKA 330 TFLKLAGPQL 340 VQMFIGDGAK 350 LVRDAFALAK 360 EKAPSIIFID 370 ELDAIGTKRF 380 DSEKAGDREV 390 QRTMLELLNQ 400 LDGFQPNTQV 410 KVIAATNRVD 420 ILDPALLRSG 430 RLDRKIEFPM 440 PNEEARARIM 450 QIHSRKMNVS 460 PDVNYEELAR 470 CTDDFNGAQC 480 KAVCVEAGMI 490 ALRRGATELT 500 HEDYMEGILE 510 VQAKKKANLQ YYA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000502 proteasome complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.