Search Results

Overview

Uniprot IDA0A5G2Q9K8
Protein NameSolute carrier family 25 member 3
Gene NameSLC25A3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
144 RMQVDPNKYKGIFNG
251 TLRDAAPKMYQEEGL
259 MYQEEGLKAFYKGVA
292 RTVEALYKFVVPKPR
297 LYKFVVPKPRSECSK
340 VSVLNKEKGSSASQV
358 LGFRGVWKGLFARII

Function

Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment. Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP. Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly. May also play a role in regulation of the mitochondrial permeability transition pore (mPTP)

Protein Sequence

10 MTSSRARRRE 20 EARPRWRVPS 30 VQVTLTGLTA 40 PFACPLTAAS 50 SPPRKMFSSV 60 AHLARANPFN 70 APHLQLVQDG 80 LAGPRSSPDG 90 PPGPPRRTRN 100 LAAAAVEEQY 110 SCDYGSGRFF 120 ILCGLGGIIS 130 CGTTHTALVP 140 LDLVKCRMQV 150 DPNKYKGIFN 160 GFSITLKEDG 170 VRGLAKGWAP 180 TFIGYSLQGL 190 CKFGFYEVFK 200 VLYSNMLGEE 210 NAYLWRTSLY 220 LAASASAEFF 230 ADIALAPMEA 240 AKVRIQTQPG 250 YANTLRDAAP 260 KMYQEEGLKA 270 FYKGVAPLWM 280 RQIPYTMMKF 290 ACFERTVEAL 300 YKFVVPKPRS 310 ECSKPEQLVV 320 TFVAGYIAGV 330 FCAIVSHPAD 340 SVVSVLNKEK 350 GSSASQVLRR 360 LGFRGVWKGL 370 FARIIMIGTL 380 TALQWFIYDS 390 VKVYFRLPRP 400 PPPEMPESLK KKLGYTQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Molecular Function GO:0005315 phosphate transmembrane transporter activity
Biological Process GO:1990547 mitochondrial phosphate ion transmembrane transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.