Search Results
Overview
| Uniprot ID | A0A5G2Q9X2 |
|---|---|
| Protein Name | Isocitrate dehydrogenase [NAD] subunit, mitochondrial |
| Gene Name | IDH3B |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 108 | LSSMKENKVAIIGKI |
| 135 | YDMRLRRKLDLFANV |
| 207 | FAFDYATKKGRSKVT |
Function
Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers
Protein Sequence
10
MAALSGVRWL
20
TRALVAAANP
30
GAWRSLSTSV
40
VAQAASRSQA
50
EDVRVEGAFP
60
VTMLPGDGVG
70
PELMHAVKEV
80
FKAASVPVEF
90
QEHHLSEVQN
100
MASEEKLEQV
110
LSSMKENKVA
120
IIGKIHTPME
130
YKGELASYDM
140
RLRRKLDLFA
150
NVVHVKSLPG
160
YMTRHNNLDL
170
VIIREQTEGE
180
YSSLEHESAR
190
GVIECLKIVT
200
RTKSQRIAKF
210
AFDYATKKGR
220
SKVTAVHKAN
230
IMKLGDGLFL
240
QCCEEVAELY
250
PKIKFETMII
260
DNCCMQLVQN
270
PYQFDVLVMP
280
NLYGNIIDNL
290
AAGLVGGAGV
300
VPGESYSAEY
310
AVFEMGARHP
320
FAQAVGRNIA
330
NPTAMLLSAS
340
NMLRHLNLEY
350
HSNMIADAVK
360
KVIKVGKVSL
370
GRLWGLGPQH
380
YFLGNLSWSL
390
LSLQVPRTLA
400
LFSATQGCSF
410
PFSWFHPLDF
420
LCLLVLICYS
430
LFPAPPMGWL
440
CNWPSKCRTL
450
QLSVWGDGEQ
460
REVVGRKRHQ
470
CHFLHTWKSI
480
RSAIPPLPPA
490
QAAAEPESLL
500
WDSRQEWPPP
510
CLTSFSWPPS
520
LLFGFHFHLH
530
HTALPPPSWA
540
LFSSSPRLLL
550
VVAVGADSRH
560
GRLQYHNRLH
570
QVCHRPPAPP
580
WGLEPFIPSN
590
LTRTIHIPSV
600
QWTREERSAS
RP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.