Overview
| Uniprot ID | A0A5G2QA48 |
|---|
| Protein Name | Signal recognition particle 54 kDa protein |
|---|
| Gene Name | SRP54 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 190 |
QAKAFKDKVDVASVI |
| 274 |
EALIEKLKHGQFTLR |
| 349 |
DGAKVFSKQPGRIQR |
| 36 |
AVFKELVKLVDPGVK |
| 43 |
KLVDPGVKAWTPTKG |
Function
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development
Protein Sequence
10
MPPLSMKRSA
20
IDLEEMASGL
30
NKRKMIQHAV
40
FKELVKLVDP
50
GVKAWTPTKG
60
KQNVIMFVGL
70
QGSGKTTTCS
80
KLAYYYQRKG
90
WKTCLICADT
100
FRAGAFDQLK
110
QNATKARIPF
120
YGSYTEMDPV
130
IIASEGVEKF
140
KNENFEIIIV
150
DTSGRHKQED
160
SLFEEMLQVA
170
NAIQPDNIVY
180
VMDASIGQAC
190
EAQAKAFKDK
200
VDVASVIVTK
210
LDGHAKGGGA
220
LSAVAATKSP
230
IIFIGTGEHI
240
DDFEPFKTQP
250
FISKLLGMGD
260
IEGLIDKVNE
270
LKLDDNEALI
280
EKLKHGQFTL
290
RDMYEQFQNI
300
MKMGPFSQIL
310
GMIPGFGTDF
320
MSKGNEQESM
330
ARLKKLMTIM
340
DSMNDQELDS
350
TDGAKVFSKQ
360
PGRIQRVARG
370
SGVSTRDVQE
380
LLTQYTKFAQ
390
MVKKMGGIKG
400
LFKGGDMSKN
410
VSQSQMAKLN
420
QQMAKMMDPR
430
VLHHMGGMAG
440
LQSMMRQFQQ
450
GAAGNMKGMM
GFNNM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005786 |
signal recognition particle, endoplasmic reticulum targeting |
| Molecular Function |
GO:0008312 |
7S RNA binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Biological Process |
GO:0006614 |
SRP-dependent cotranslational protein targeting to membrane |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.