Overview
| Uniprot ID | A0A5G2QAE1 |
|---|
| Protein Name | Actin-related protein 2/3 complex subunit 4 |
|---|
| Gene Name | TTLL3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 101 |
VRVSIAVKQADEIEK |
| 108 |
KQADEIEKILCHKFM |
| 113 |
IEKILCHKFMRFMMM |
| 59 |
QVVERHNKPEVEVRS |
| 68 |
EVEVRSSKELLLQPV |
| 84 |
ISRNEKEKVLIEGSI |
Function
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)
Protein Sequence
10
MGFAGVTCLP
20
HYPQNFCRED
30
EVLFWTATLR
40
PYLSAVRATL
50
QAALCLENFS
60
SQVVERHNKP
70
EVEVRSSKEL
80
LLQPVTISRN
90
EKEKVLIEGS
100
INSVRVSIAV
110
KQADEIEKIL
120
CHKFMRFMMM
130
RAENFFILRR
140
KPVEGYDISF
150
LITNFHTEQM
160
YKHKLVDFVI
170
HFMEEIDKEI
180
SEMKLSVNAR
190
ARIVAEEFLK
200
NVSEGPSCFP
210
SRSRKTSGLC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005885 |
Arp2/3 protein complex |
| Molecular Function |
GO:0003779 |
actin binding |
| Biological Process |
GO:0030041 |
actin filament polymerization |
| Biological Process |
GO:0034314 |
Arp2/3 complex-mediated actin nucleation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.