Overview
| Uniprot ID | A0A5G2QAH0 |
|---|
| Protein Name | Coatomer subunit epsilon |
|---|
| Gene Name | COPE |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 226 |
NRYLSQLKDAHRTHP |
| 241 |
FIKEYHAKENDFDRL |
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors
Protein Sequence
10
MAPPAPGPAS
20
GGSGEVDELF
30
DVKNAFYIGS
40
YQQCINEAQR
50
VKPSSPERDV
60
ERDVFLYRAY
70
LAQRKFGVVL
80
DEIKPSSAPE
90
LQAIRMFAEY
100
LASDSRRDAI
110
VAELDREMSR
120
SVDVTNTTFL
130
LMAASIYFHD
140
QNPDAALRTL
150
HQGDSLECMA
160
MTVQILLKLD
170
RLDLARKELK
180
KMQDQDEDAT
190
LTQLATAWVN
200
LAVDSSHPET
210
LINLIVLSQH
220
LGKPPEVTNR
230
YLSQLKDAHR
240
THPFIKEYHA
250
KENDFDRLVL
QYAPSA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030663 |
COPI-coated vesicle membrane |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0006890 |
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.