Search Results

Overview

Uniprot IDA0A5G2QAK4
Protein NameCysteine--tRNA ligase, cytoplasmic
Gene NameCARS1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
152 YNSLTRSKDVFVPQD
161 VFVPQDGKRVTWYCC
398 SEGHCYGKLVPEAVG
440 FALWKASKPGEPSWP
525 CKMSKSLKNFITIKD
531 LKNFITIKDALKKHS
605 REETELNKCFYDKKA
611 NKCFYDKKAAVHEAL
753 EGLPTVVKLVDRDTL

Function

Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys)

Protein Sequence

10 MGMRGGAHPT 20 DSPRPPASSA 30 SVPTQLLCLE 40 VAHPRPVSLL 50 KAVLLGVGDG 60 LPVQPRGPPG 70 RAGRRGLGAS 80 RGCVWEAVMS 90 APEPGGGGLW 100 PRCAQSKRGR 110 GAARLPVVPP 120 RPAPDPAPLP 130 AGRGRRAQPQ 140 WAPPAGSEPC 150 QLRLYNSLTR 160 SKDVFVPQDG 170 KRVTWYCCGP 180 TVYDASHMGH 190 ARSYVSFDIL 200 RRVLRDYFRF 210 DVFYCMNITD 220 VDDKIIRRAR 230 QNYLFERYRE 240 KQPSAAQLLE 250 DVHAALQPFA 260 AKLKETTDPD 270 KKQMLERLER 280 AVTRAAEPLE 290 EAVRASLVGE 300 ELDGRVQVLL 310 AEAKDLLSDW 320 LDSTHGSEVT 330 DNSIFSQLPK 340 FWEAEFHKDM 350 EALNVLPPDV 360 LTRVSEYVPE 370 IVDFVQKIMD 380 NGYGYASNGS 390 VYFDTVKFAN 400 SEGHCYGKLV 410 PEAVGDQRAL 420 QEGEGDLSIS 430 AERLSEKRSP 440 NDFALWKASK 450 PGEPSWPCPW 460 GRGRPGWHIE 470 CSAMAGTLLG 480 ASMDIHGGGF 490 DLRFPHHDNE 500 LAQSEAYFEN 510 DCWVRYFLHT 520 GHLTIAGCKM 530 SKSLKNFITI 540 KDALKKHSAR 550 QLRLAFLMHA 560 WKDTLDYSSN 570 TMESALQYER 580 FLNEFFLNVK 590 DLLRAPGDVT 600 GQFEKWEREE 610 TELNKCFYDK 620 KAAVHEALCD 630 NVDTRTALEE 640 MRALVSQCNL 650 YTAARKAARR 660 RPNRALLASV 670 ANYLTHMLKI 680 FGAIEEESPL 690 GFPVGAPGTS 700 LSLESTVMPY 710 LQVLSEFREG 720 VRSIARERRV 730 PEVLQLSDAL 740 RDDILPELGV 750 RLEDHEGLPT 760 VVKLVDRDTL 770 LREREEKKRV 780 EEEKRRKKEE 790 AARKRQEQEA 800 AKLAKMKVPP 810 GEMFLSESDK 820 YSKFDENGLP 830 THDAEGKELS 840 KGQAKKLKKL 850 FEAQEKLHKE 860 YLQLVQNGGF P

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004817 cysteine-tRNA ligase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0006423 cysteinyl-tRNA aminoacylation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.