Search Results

Overview

Uniprot IDA0A5G2QB32
Protein NameCalpain-2 catalytic subunit
Gene NameCAPN2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
226 KAPPNLFKIIQKALQ
230 NLFKIIQKALQKGSL
26 GSHERAVKYLNQDYA
260 VTFQKLVKGHAYSVT
280 ESRGSLQKLIRIRNP
568 LAKRQDIKSDGFSIE
629 MNSYEMRKALEEAGF
637 ALEEAGFKLPCQLHQ
69 ELGPYSGKTRGIEWK
7 *MAGIAAKLAKDREA

Function

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs

Protein Sequence

10 MAGIAAKLAK 20 DREAAEGLGS 30 HERAVKYLNQ 40 DYAELRDQCL 50 EAGALFQDPS 60 FPALPSSLGF 70 KELGPYSGKT 80 RGIEWKRPTE 90 ICDNPQFIIG 100 GATRTDICQG 110 ALGDCWLLAA 120 IASLTLNEEV 130 LARVVPLDQS 140 FQENYAGIFR 150 FQFWQYGEWV 160 EVVVDDRLPT 170 KDGELLFVHS 180 AEGSEFWSAL 190 LEKAYAKING 200 CYEALSGGAT 210 TEGFEDFTGG 220 IAEWYELRKA 230 PPNLFKIIQK 240 ALQKGSLLGC 250 SIDITSAADS 260 EAVTFQKLVK 270 GHAYSVTGAE 280 EVESRGSLQK 290 LIRIRNPWGE 300 VEWTGQWNDN 310 CPNWNTVDPE 320 VRESLTRRHE 330 DGEFWMSFSD 340 FLRHYSRLEI 350 CNLTPDTLTS 360 DSYKKWKLTK 370 MDGNWRRGST 380 AGGCRNYPNT 390 FWMNPQYLIK 400 LEEEDEDQED 410 GESGCTFLVG 420 LIQKHRRRQR 430 KMGEDMHTIG 440 FGIYESPRQL 450 TGQTNIHLSK 460 NFFLTHRARE 470 RSDTFINLRE 480 VLNRFKLPPG 490 EYILVPSTFE 500 PNKDGDFCIR 510 VFSEKKADYQ 520 VVDDEIEADL 530 EENDASEDDI 540 DDGFRRLFAQ 550 LAGEDAEISA 560 FELQTILRRV 570 LAKRQDIKSD 580 GFSIETCKIM 590 VDMLDSDGSG 600 KLGLKEFYIL 610 WTKIQKYQKI 620 YREIDVDRSG 630 TMNSYEMRKA 640 LEEAGFKLPC 650 QLHQVIVARF 660 ADDQLIIDFD 670 NFVRCLVRLE 680 TLFRIFKQLD 690 SENTGTIELD 700 LISWLCFSVL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0004198 calcium-dependent cysteine-type endopeptidase activity
Biological Process GO:0006508 proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.