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Overview

Uniprot ID	A0A5G2QB59
Protein Name	Malic enzyme
Gene Name	ME2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
132	GHIFRRPKGLFISIS

Function

NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate

Protein Sequence

10 MMLSRFKIVA 20 TPCTLACRHL 30 HIKEKGKPLM 40 LNPRTNKGMA 50 FTLQERQMLG 60 LQGLLPPKIE 70 TQDIQALRFH 80 RNVKKLNGPL 90 EKYIYIMGIQ 100 ERNEKLFYRI 110 LQDDIETLMP 120 IVYTPTVGLA 130 CSQYGHIFRR 140 PKGLFISISD 150 RGHVRSIVDN 160 WPENHVKAVV 170 VTDGERILGL 180 GDLGVYGMGI 190 PVGKLCLYTA 200 CAGIRPDRCL 210 PVCIDVGTDN 220 PALLKDPFYM 230 GLYQKRDRSQ 240 RYDDLIDEFM 250 KAITDRYGRN 260 ILIQFEDFGN 270 HNAFRFLRKY 280 REKYCTFNDD 290 IQGTAAVALA 300 GLLAAQKVIG 310 KSISEHKILF 320 LGAGEAALGI 330 ANLIVMAMVE 340 NGLSEEEAQK 350 KIWMVDKFGL 360 LFKGRKAKID 370 SHQEPFAHPA 380 PDNIPDNFED 390 AVNILKPSAI 400 IGVAGAGRLF 410 THNVIKAMAD 420 INERPIIFAL 430 SNPTAQAECT 440 AEEAYTLTEG 450 RCLFASGSPF 460 GPVKLSDGQV 470 FTPGQGNNVY 480 IFPGVALAVI 490 LCNTRHISDH 500 VFLEAAKALT 510 SQLTDKELAQ 520 GRLYPPLANI 530 QEVSINIAIK 540 APVAYGDSQA 550 RGLIRAVAAG 560 LCQSHSNEGS 570 KRVCDPHHSS 580 QQRRILNPLS 590 KTRDQTCNLM GS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Molecular Function	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0051287	NAD binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.