Search Results

Overview

Uniprot IDA0A5G2QBH8
Protein NameProlyl 4-hydroxylase subunit alpha-1
Gene NameP4HA1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
229 DKALLLTKKLLELDP
230 KALLLTKKLLELDPE
299 LCRGEGIKMTPRRQK
320 HDGNRNPKFILAPAK
327 KFILAPAKQEDEWDK
435 PHFDFARKDEPDAFK
487 CPVLVGNKWVSNKWL
492 GNKWVSNKWLHERGQ
72 RLTSTATKDPEGFVG

Function

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins

Protein Sequence

10 MIWCILVAGI 20 LLPQSLAHPG 30 FFTSIGQMTD 40 LIHTEKDLVT 50 SLKDYIKAEE 60 DKLEQIKKWA 70 EKLDRLTSTA 80 TKDPEGFVGH 90 PVNAFKLMKR 100 LNTEWSELEN 110 LVLKDMSDGF 120 ISNLTIQRQY 130 FPNDEDQVGA 140 AKALLRLQDT 150 YNLDTDTISK 160 GDLPGVKHKS 170 FLTVEDCFEL 180 GKVAYTEADY 190 YHTELWMEQA 200 LRQLDEGEVS 210 TIDKVSVLDY 220 LSYAVYQQGD 230 LDKALLLTKK 240 LLELDPEHQR 250 ANGNLKYFEY 260 IMAKEKEANK 270 SASDDQSNQK 280 TTLKKKGVAV 290 DYLPERQKYE 300 MLCRGEGIKM 310 TPRRQKKLFC 320 RYHDGNRNPK 330 FILAPAKQED 340 EWDKPRIIRF 350 HDIISDAEID 360 IVKDLAKPRL 370 SRATVHDPET 380 GKLTTAQYRV 390 SKSAWLSGYE 400 NPVVSRLNMR 410 IQDLTGLDVS 420 TAEELQVANY 430 GVGGQYEPHF 440 DFARKDEPDA 450 FKELGTGNRI 460 ATWLFYGTAV 470 FWYNLFASGE 480 GDYSTRHAAC 490 PVLVGNKWVS 500 NKWLHERGQE 510 FRRPCTLSEL E

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005788 endoplasmic reticulum lumen
Molecular Function GO:0005506 iron ion binding
Molecular Function GO:0031418 L-ascorbic acid binding
Molecular Function GO:0004656 procollagen-proline 4-dioxygenase activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.