Overview
| Uniprot ID | A0A5G2QBJ4 |
|---|
| Protein Name | Coatomer subunit zeta |
|---|
| Gene Name | COPZ1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 61 |
DGDRLFAKYYDDTYP |
| 71 |
DDTYPSVKEQKAFEK |
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex
Protein Sequence
10
MQRHLSIPLQ
20
SQWDQGKGFG
30
LLVVARAFRT
40
EGMFISLQEP
50
SLYTVKAILI
60
LDNDGDRLFA
70
KYYDDTYPSV
80
KEQKAFEKNI
90
FNKTHRTDSE
100
IALLEGLTVV
110
YKSSIDLYFY
120
VIGSSYENEL
130
MLMAVLNCLF
140
DSLSQMLRKN
150
VEKRALLENM
160
EGLFLAVDEI
170
VDGGVILESD
180
PQQVVHRVAL
190
RGEDVPLTEQ
200
TVSQVLQSAK
EQIKWSLLR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030126 |
COPI vesicle coat |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0006890 |
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.