Overview
| Uniprot ID | A0A5G2QBS5 |
|---|
| Protein Name | Nuclear RNA export factor 1 |
|---|
| Gene Name | NXF1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 127 |
GRGPFRWKCGEGNRR |
| 275 |
ALKAVNYKILDRENR |
Function
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export
Protein Sequence
10
MKAGGRRTRG
20
NSASQAQVLG
30
GACNAKSRPR
40
LVRSSNAHAR
50
LPVVPPITVG
60
RRLRATRWPH
70
KCGGIRRRST
80
SAGRAWAFGR
90
LPVSRAATEP
100
APARCAMADE
110
GKSYNEHDDR
120
VSFPQRRKKG
130
RGPFRWKCGE
140
GNRRSARGGS
150
SIRSSRLEED
160
DRDVAVSDAQ
170
DVPRLRYNPY
180
APRPNRRGDG
190
WHERSRIHVT
200
VPLRRDRVPP
210
ERGGAGTSQD
220
GTSKNWFKIT
230
IPYGRKYDKS
240
WLLGMIQSKC
250
SVPFTPIEFH
260
YENTRAQFFV
270
EDASTASALK
280
AVNYKILDRE
290
NRRISIIINS
300
SPPPHTVQNE
310
LKPEQVEQLK
320
LIMSKRYDGS
330
QQALDLKGLR
340
TDPDLVAQNI
350
DVVLNRRSCM
360
AAALRIIEEN
370
IPELLSLNLS
380
NNKLYRLDDL
390
SNIVQKAPNL
400
KILNLSGNEL
410
KSERELDKIK
420
GLKLEELWLD
430
GNTLCDTFRD
440
QSTYISAIRE
450
RFPKLLRLDG
460
HELPPPIAFD
470
VEAPTMLPPC
480
KGSYFGTETL
490
KNLVLHFLQQ
500
YYAVYDSGDR
510
QRLLDAYHDG
520
ACCSLSIPFI
530
PQNPARSNLA
540
EYFKDSRNVK
550
KLKDPSLRFR
560
LLKHTRLNVV
570
AFLNELPKTQ
580
HDINSFVVDI
590
SAQTSTLLCF
600
SVNGVFKEVD
610
GKSRDSLRAF
620
TRTFVAVPGS
630
NSGLCIVNDE
640
LFVRNASPDE
650
IQRAFAMPAP
660
TPSSSPVPTL
670
SPEQQEMLQA
680
FSTQSGMNLE
690
WSQKCLQDNN
700
WDYTRSAQAF
710
THLKVREWVA
720
KRDLQAFKRV
K
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0042405 |
nuclear inclusion body |
| Cellular Component |
GO:0005643 |
nuclear pore |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000346 |
transcription export complex |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0016973 |
poly(A)+ mRNA export from nucleus |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.