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Overview

Uniprot ID	A0A5G2QBV9
Protein Name	Long-chain-fatty-acid--CoA ligase
Gene Name	ACSL1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
428	IQSSLGGKVRLMVTG

Function

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation

Protein Sequence

10 MMQAHELFRY 20 FRMPELVDFQ 30 QYVRTLPTNT 40 LMGFGAFAAL 50 TTFWYATRPR 60 ALKPPCDLAM 70 QSVEVAGSDG 80 ARRSAILDSD 90 EPLAYFYDDV 100 RTLYEGFQRG 110 IRVSNNGPCL 120 GSRKPDQPYE 130 WLSYKQVEDM 140 SECVGSALIH 150 KGFKAGPENF 160 VGIFAQNRPE 170 WVIIEQGCFA 180 YSMVVVPLYD 190 TLGTEAITYI 200 INKGELSLVF 210 VDKPEKANLL 220 LEGVENKLIP 230 GLKTIILMDS 240 YGIDLLERGK 250 KCGVEIMSMK 260 ALEDLGRANR 270 RKPKPPAPED 280 LAVICFTSGT 290 TGNPKGAMIT 300 HRNVVSDCSA 310 FVKVTEKTFS 320 PSSDDTLISF 330 LPLAHMFERV 340 VECVMLCHGA 350 KIGFFQGDIR 360 LLMDDLKALQ 370 PTIFPVVPRL 380 LNRMFDRIFG 390 QANTTLKRWL 400 LDFASKRKEA 410 ELRSGIIRNN 420 SLWDKLIFHK 430 IQSSLGGKVR 440 LMVTGAAPVS 450 ATVLTFLRAA 460 LGCQFYEGYG 470 QTECTAGCSL 480 TVPGDWTAGH 490 VGAPMPCSLI 500 KLVDVEEMNY 510 LAAKGEGEVC 520 VKGPNVFQGY 530 LKDPAKTAEA 540 LDKDGWLHTG 550 DIGKWLPGEY 560 IAPEKIENIY 570 LRSEPVAQVF 580 VHGESLQAFL 590 IAIVVPDVET 600 LGHWAQKRGF 610 VGSFEELCRN 620 KDVKKAILED 630 MLRLGRDAGL 640 KSFEQVRGIS 650 LHPELFSIDN 660 GLLTPTMKAK 670 RPELRNYFRS 680 QIDELYSTVK V

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0005741	mitochondrial outer membrane
Molecular Function	GO:0047676	arachidonate-CoA ligase activity
Molecular Function	GO:0005524	ATP binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.