Overview
| Uniprot ID | A0A5G2QC29 |
|---|
| Protein Name | Polypyrimidine tract-binding protein 3 |
|---|
| Gene Name | PTBP3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 21 |
GNDNKKFKGDRPPCS |
| 371 |
SGQRLYGKVLRATLS |
| 451 |
TEAGCSVKAFKFFQK |
| 454 |
GCSVKAFKFFQKDRK |
Function
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform
Protein Sequence
10
MNSSTPSTGV
20
FANGNDNKKF
30
KGDRPPCSPS
40
RVLHLRKIPS
50
DVTEAEVISL
60
GLPFGKVTNL
70
LMLKGKSQAF
80
LEMASEEAAV
90
TMVNYYTPVT
100
PHLRSQPVFI
110
QYSNHRELKT
120
DNLPNQARAQ
130
AALQAVSAVQ
140
SGSLGLPGAP
150
TNEGTILPGQ
160
SPVLRIIIEN
170
LFYPVTLEVL
180
HQIFSKFGTV
190
LKIITFTKNN
200
QFQALLQYAD
210
PLNAHYAKMA
220
LDGQNIYNAC
230
CTLRIDFSKL
240
TSLNVKYNND
250
KSRDFTRLDL
260
PTGDGQPSLE
270
PPMAAAFGLS
280
VPAGLGPGAL
290
GPLAITSSAV
300
TGRMAMPGTG
310
GIPGNSVLLV
320
TNLNPDLVTP
330
HGLFILFGVY
340
GDVHRVKIMF
350
NKKENALVQM
360
ADANQAQLAM
370
NHLSGQRLYG
380
KVLRATLSKH
390
QAVQLPREGQ
400
EDQGLTKDFS
410
NSPLHRFKKP
420
GSKNFQNIFP
430
PSATLHLSNI
440
PPSVTVDDLK
450
NLFTEAGCSV
460
KAFKFFQKDR
470
KMALIQLGSV
480
EEAIQALIEL
490
HNHDLGENHH
500
LRVSFSKSTI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0043249 |
erythrocyte maturation |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.