Search Results
Overview
| Uniprot ID | A0A5G2QC33 |
|---|---|
| Protein Name | Hydroxymethylglutaryl-CoA synthase |
| Gene Name | HMGCS1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 327 | PYCKLVQKSLARMLL |
| 384 | SSELFNQKTKASLLV |
| 463 | IASLCDLKSRLDSRT |
| 552 | EHIPSPAKKVPRLPA |
Function
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA
Protein Sequence
10
MESLKNVCPA
20
LTGGRERITL
30
TQPGGKMWTT
40
VPGGGNRVTD
50
LETAVLYPSH
60
SFFTMPGSLP
70
LNAEACWPKD
80
VGIVALEIYF
90
PSQYVDQAEL
100
EKYDGVAAGR
110
YTIGLGQAKM
120
GFCTDREDIN
130
SLCMTVVQNL
140
MERNSLSYDC
150
IGRLEVGTET
160
IIDKSKSVKT
170
NLMQLFEESG
180
NTDIEGIDTI
190
NACYGGTAAV
200
FNAVNWIESS
210
SWDGRYALVV
220
AGDIAVYAAG
230
NARPTGGVGA
240
IALLIGPNAP
250
LIFERGLRGT
260
HMQHAYDFYK
270
PDMLSEYPIV
280
DGKLSIECYL
290
SALDRCYSVY
300
RKKIHARWQK
310
EGNDKDFTLN
320
DFGFMVFHSP
330
YCKLVQKSLA
340
RMLLNDFLND
350
QNRDKNSIYS
360
GLEAFGDVKL
370
EDTYFDRDVE
380
KAFMKASSEL
390
FNQKTKASLL
400
VSNQNGNMYT
410
SSLYGCLASV
420
LAQYSPQELA
430
GKRIGMFSYG
440
SGLAATLYSL
450
KVTQDATPGS
460
ALDKIIASLC
470
DLKSRLDSRT
480
CVAPDVFTEN
490
MKLREDTHHL
500
VNYIPQSSID
510
SLFEGTWYLV
520
RVDEKHRRTY
530
ARRPSRNEST
540
LDEGVELVHS
550
STATEHIPSP
560
AKKVPRLPAT
570
AAEPEVAVIS
NGEH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity |
| Biological Process | GO:0006084 | acetyl-CoA metabolic process |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0010142 | farnesyl diphosphate biosynthetic process, mevalonate pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.