Search Results

Overview

Uniprot IDA0A5G2QCX2
Protein NameBasement membrane-specific heparan sulfate proteoglycan core protein
Gene NameHSPG2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1325 KVAAYGGKLRYSLSY
1707 VTFICTAKSKSPAYT
1709 FICTAKSKSPAYTLV
279 DEADCPVKRPEDVCG
713 GPQCNKCKAGFFGDA

Function

Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6

Protein Sequence

10 MTNPLLPPHF 20 LPQLEDAGSE 30 AFREVSEAVV 40 DTLESEYLKI 50 PGDQVVSVVF 60 IKELDSWVFV 70 ELDVGSEGNA 80 DGAQIQEVLH 90 AVISSGSIAS 100 YVTSPQGFQF 110 RRLGTVPQFS 120 RVCTEAEFAC 130 HRYNECVALE 140 YRCDRRPDCR 150 DMSDELDCEE 160 PVPVLSSLPP 170 TLAETPPLPP 180 SPPEPEAATA 190 RQLPATPAPQ 200 ALFPSPDKAA 210 PCGPHEATCR 220 SGHCIPKDYV 230 CDGQEDCRDG 240 SDELDCGPAP 250 PCEPNEFPCG 260 NGHCALKLWR 270 CDGDFDCEDR 280 TDEADCPVKR 290 PEDVCGPTQF 300 RCVSTNTCIP 310 ASFHCDEESD 320 CPDRSDEFGC 330 MPPQVVTPPQ 340 ESIQASRGQT 350 VTFTCVAIGV 360 PTPIINWRLN 370 WGHIPSHPRV 380 TVTSEGGRGT 390 LIIRDVKEAD 400 QGAYTCEAMN 410 ARGMVFGIPD 420 GVLELIPQRG 430 PCPDGHFYLE 440 QSASCLPCFC 450 FGVTNVCQSS 460 RRFRDKIRLR 470 FDQPNDFKGV 480 NVTMPSQPGM 490 PPLSSTQLQI 500 DAALQEFQLV 510 DLSRRFLVHD 520 SFWALPEQFL 530 GNKVDSYGGF 540 LHYKVRYELA 550 RGTLEPVQRP 560 DVVLVGAGHR 570 LLSRGHTPTQ 580 PGTLNQRQVQ 590 FSEEHWVHES 600 GRPVQRAEML 610 QVLQSLEAVL 620 IQTVYNAKMA 630 SVGLSDISMD 640 TTVTYATSHG 650 RAHSVEECRC 660 PIGYSGLSCE 670 SCDAHFTRVP 680 GGPYLGTCSG 690 CSCNGHASSC 700 DPVYGHCLNC 710 QHNTEGPQCN 720 KCKAGFFGDA 730 TKGTATACRP 740 CPCPYIDASR 750 RFSDTCFLDT 760 DGQATCDACA 770 PGYTGRRCES 780 CAPGYEGNPI 790 QPGGKCRPTN 800 QQIVRCDERG 810 STGTSGEACR 820 CKNNVVGRLC 830 NECVAGSFHL 840 SARNPDGCLK 850 CFCMGVSRQC 860 TSSSWSRAQV 870 LGASEEPAQF 880 SLTNAAGTHT 890 TSEGISSPTP 900 GELAFSSFHS 910 LLSGPYFWSL 920 PSRFLGDKVT 930 SYGGELRFTV 940 TQRPQPGSVP 950 LHGQPLVVLQ 960 GNNIILEHHT 970 SQEPSPGQPS 980 TFTVPFREQA 990 WQRPDGQPAT 1000 REHLLMALAG 1010 IDTLLIQASY 1020 TQRPAESRVS 1030 GISMDVAVPE 1040 DTGQDPALEV 1050 EQCTCPPGYR 1060 GPSCQDCDTG 1070 YTRMPSGLYL 1080 GTCERCSCHG 1090 HTEVCEPETG 1100 ACQGCQHHTE 1110 GPRCEQCQPG 1120 YYGDAQRGTP 1130 QDCQPCPCHG 1140 APAAGQATHT 1150 CFLDTDGHPT 1160 CDACSPGHSG 1170 RHCLGFHLWC 1180 PSTSGDDGQV 1190 PEPISCSCDP 1200 QGSISNQCDA 1210 AGQCQCKAQV 1220 EGLTCSHCRP 1230 HHFYLSASNP 1240 DGCLPCFCMG 1250 VTQQCSSSSY 1260 TRHLISTRFA 1270 PGDFQGFALV 1280 NPQRNSRLTG 1290 GFTVEPVPEG 1300 AQLSFGNFAN 1310 LGHESFYWQL 1320 PETYQGDKVA 1330 AYGGKLRYSL 1340 SYTAGAQGSP 1350 LSDPDVQITG 1360 NNIMLVASQP 1370 ALQGPERRSY 1380 EIIFREEFWR 1390 RPDGQPATRE 1400 HLLMALADLD 1410 ELLVRATFSS 1420 MPLAASISAV 1430 SLEVAQPGPS 1440 EGPRAPEVEE 1450 CRCPPGYVGS 1460 SCQDCAPGYT 1470 RTGSGLYLGH 1480 CELCECNGHS 1490 DLCHPETGAC 1500 SQCQHNAAGE 1510 FCELCAPGYY 1520 GDATAGTPED 1530 CQPCACPLTN 1540 PENMFSRTCE 1550 SLGAGGYRCT 1560 ACEPGYTGQY 1570 CEQCAPGYVG 1580 NPNVRGGRCL 1590 PQADQAPLVV 1600 QVQPPRSVVP 1610 QGGPHSLRCQ 1620 VSGSPPHYFY 1630 WSREDGRPLP 1640 SSTQQRHQGS 1650 ELHFPSVQPS 1660 DAGVYICTCR 1670 NLHHANTSRA 1680 ELLVTEAPSK 1690 PITVTVEEQR 1700 SQSVRPGTDV 1710 TFICTAKSKS 1720 PAYTLVWTRL 1730 HNGKLPTRAM 1740 DFNGILTIRN 1750 VQPSDAGTYV 1760 CTGSNMFAMD 1770 QGTATLHVQA 1780 SGTPSAPMAS 1790 IHPPQLTVQP 1800 GQLAEFRCSA 1810 TGNPTPTLEW 1820 TGGPGGQLPQ 1830 KAQILGGILR 1840 LPAVEPSDQA 1850 QYLCHAHSSA 1860 GQHVARAVLH 1870 VHGGNGPRVQ 1880 VSPERTQVHE 1890 GRTVRLYCRA 1900 AGVPSATITW 1910 RKEGGSLPPQ 1920 ARSERTDIAT 1930 LLIPAITTAD 1940 AGFYLCVATS 1950 PAGTAQARIQ 1960 VVVLPASGAS 1970 SPPPVRIESS 1980 SPSVTEGQTL 1990 DLNCVVTGLA 2000 YTQVTWYKRG 2010 GSLPPHAQTH 2020 GSRLRLHQVS 2030 PADSGEYVCR 2040 VVLGSGPLES 2050 SVLVTIEATP 2060 SPGPIPPVRI 2070 ESSSPTVAEG 2080 QTLDLNCVVA 2090 GQAHAQVTWY 2100 KRGGSLPARH 2110 QVRGSRLYIF 2120 QASPADAGEY 2130 VCRASNGVEA 2140 TITVTVTRTQ 2150 GANFAYPPGS 2160 TPIRIEPSSS 2170 HVAEGQTLDL 2180 NCVVPGQAHA 2190 QVTWHKRGGS 2200 LPARHQTHGS 2210 LLRLYQVSPA 2220 DSGEYVCRIV 2230 GGSVPLEASV 2240 LVTIEPADSV 2250 PALGVTPPVR 2260 IESSSSHVAE 2270 GQTLDLNCLV 2280 SGQAHAQVTW 2290 HKRGGSLPAR 2300 HQVHGSRLRL 2310 PQVTPADSGE 2320 YVCRVVSSSG 2330 TQEASVLVTI 2340 QQRLGPSRPQ 2350 SVVYPVRIES 2360 SSDSLANGHT 2370 LDLNCLVASQ 2380 APHTITWYKR 2390 GGSLPSRHQI 2400 VGSRLRIPQV 2410 TPADSGEYVC 2420 HVSNGAGSQE 2430 TSLIVTIQGG 2440 GSSHVPSVSP 2450 PIRIESSSPT 2460 VVEGQTLDLT 2470 CVVAGQPQAT 2480 ITWYKRGGSL 2490 PARHQAHGSH 2500 LRLHQMSVAD 2510 SGEYVCRANN 2520 NIDAQEASIV 2530 VSVSPSTRSP 2540 AVPGGAMPIR 2550 IESSSSHVAE 2560 GQTLDLNCVV 2570 PGQAHAQVTW 2580 HKRGGSLPTH 2590 HQAHGSRLRL 2600 YQLSPADSGE 2610 YVCRVVSSSG 2620 PLEASVLVTI 2630 EASGSGTVLV 2640 PAAGGTPPIR 2650 IETSSSHVAE 2660 GQTLDLKCVV 2670 PGQAHAQVTW 2680 HRRGGSLPAR 2690 HQVHGPLLRL 2700 NQVSPADSGE 2710 YSCRVTGSSG 2720 TQEASVLVTI 2730 EASSPSPIPA 2740 PGLAQPIYIE 2750 ASSSHVTEGQ 2760 TLDLNCVVPG 2770 QAHAQVTWHK 2780 HGGSLPARHQ 2790 THGSRLRLHQ 2800 VSQADSGEYV 2810 CRVVGISGPE 2820 LEASFTVTVP 2830 PSAGSSYRLR 2840 SPVISIDPPS 2850 STVQQGQDAS 2860 FKCLIHDGAA 2870 PISLEWKTRN 2880 QELEDNVHIS 2890 PNGSIITIVG 2900 TRPSNHGAYR 2910 CVASNAYGVA 2920 QSVVTLSVHG 2930 PPTVSVLPEG 2940 PVRVKEGKAI 2950 TLECVSAGEP 2960 RSSARWTRIG 2970 APTNLEQRLH 2980 GLLDSHTLLQ 2990 ISSAKPSDAG 3000 IYVCLAQNAL 3010 GTAQKRVEVI 3020 VDTGIMAPGA 3030 PQVQVEEAEL 3040 TVEAGHTATL 3050 RCSATGSPTP 3060 TIHWSKLRSP 3070 LPWQHQLEGD 3080 TLIIPRVAQQ 3090 DSGQYICNAT 3100 SPAGHAEATI 3110 ALHVESPPYA 3120 TTVPEHASVR 3130 AGETVHLQCL 3140 AHGTPPLTFQ 3150 WSRVGGNLPS 3160 RVTARKEMLL 3170 FEPAAPEDSG 3180 RYRCRVTNKV 3190 GSAEAFAQVL 3200 VQGPSGSLPA 3210 TPHPAGATPA 3220 VQVTPQLETK 3230 SIGASVEFHC 3240 IVPSDQGTQL 3250 RWVKEGGQLP 3260 PGHSVHDGVL 3270 RIQNLDQSCQ 3280 GTYVCQAYGP 3290 WGQAQASAQL 3300 VVQALPSVLI 3310 NIRTSVQTVV 3320 VGHSVEFECL 3330 ALGDPKPQVT 3340 WSKVGGPLRP 3350 GIVQTGGIVR 3360 IAHVELADAG 3370 QYRCTATNAA 3380 GTTQSHVLLL 3390 VQALPQISTP 3400 PEVRVPAGSA 3410 AVFPCMASGY 3420 PTPDISWSKL 3430 DGNLPPDSRL 3440 ENNMLLLPSV 3450 RPQDAGTYVC 3460 TATNRQGKVK 3470 AFAHLQVPER 3480 VVPYFTQTPH 3490 SFLPLPTIKD 3500 AYRKFEIKIT 3510 FRPDSADGML 3520 LYNGQKRIPG 3530 SPTNLANRQP 3540 DFISFGLVGG 3550 RPEFRFDAGS 3560 GMATIRHPTP 3570 LALGQFHTVT 3580 LLRSLTQGSL 3590 IVGSLTPVNG 3600 TSQGKFQGLD 3610 LNEELYLGGY 3620 PDYGAIPKAG 3630 LSSGFVGCVR 3640 ELRIQGEEIV 3650 FHDLNLTAHG 3660 ISHCPTCRDR 3670 PCQNGGHCQD 3680 SESSSYVCMC 3690 PAGFTGSRCE 3700 HSQALHCHPE 3710 ACGPDATCVN 3720 RPDGRGYTCR 3730 CHLGRSGRRC 3740 EEGVTVTTPS 3750 MSGTGSYLAL 3760 PALTNTHHEL 3770 RLDVEFKPLA 3780 PDGILVFSGG 3790 QSGPVEDFVS 3800 LAMVGGHLEF 3810 RYELGSGLAI 3820 LRSSEPLALG 3830 RWHHVSAERF 3840 NKDGSLRVNG 3850 GRPVLRSSPG 3860 KSQGLNLHTL 3870 LYLGGVEPSV 3880 QLPPATNVSA 3890 HFHGCIGEVS 3900 VNGKRLDLTY 3910 SFLGSRGIGQ 3920 CYDSSPCERQ 3930 PCQNGATCMP 3940 AGEYEFQCLC 3950 RDGFKGDLCE 3960 HEENPCQLHE 3970 PCLHGGTCQG 3980 TRCLCPPGFS 3990 GPRCQQGSVH 4000 GIAESDWHLE 4010 GSGGNDAPGQ 4020 YGAYFYDDGF 4030 LALPGRVFSR 4040 SLPEVPETIE 4050 LEVRTSTASG 4060 LLLWQGVEVG 4070 ESGRGKDFIS 4080 LGLQDGHLVF 4090 SYQLGSGEAR 4100 LVSEDPINDG 4110 EWHRVTALRE 4120 GRRGSIQVDG 4130 EELVSGQSPG 4140 PNVAVNTKGS 4150 VYIGGAPDVA 4160 ALTGGRFSSG 4170 ITGCIKNLVL 4180 HSARPGALPP 4190 QPLDLQHRAQ 4200 AGANMRPCPS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0005796 Golgi lumen
Molecular Function GO:0005509 calcium ion binding
Biological Process GO:0001525 angiogenesis
Biological Process GO:0007420 brain development
Biological Process GO:0030154 cell differentiation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.