Search Results
Overview
| Uniprot ID | A0A5G2QCX2 |
|---|---|
| Protein Name | Basement membrane-specific heparan sulfate proteoglycan core protein |
| Gene Name | HSPG2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1325 | KVAAYGGKLRYSLSY |
| 1707 | VTFICTAKSKSPAYT |
| 1709 | FICTAKSKSPAYTLV |
| 279 | DEADCPVKRPEDVCG |
| 713 | GPQCNKCKAGFFGDA |
Function
Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6
Protein Sequence
10
MTNPLLPPHF
20
LPQLEDAGSE
30
AFREVSEAVV
40
DTLESEYLKI
50
PGDQVVSVVF
60
IKELDSWVFV
70
ELDVGSEGNA
80
DGAQIQEVLH
90
AVISSGSIAS
100
YVTSPQGFQF
110
RRLGTVPQFS
120
RVCTEAEFAC
130
HRYNECVALE
140
YRCDRRPDCR
150
DMSDELDCEE
160
PVPVLSSLPP
170
TLAETPPLPP
180
SPPEPEAATA
190
RQLPATPAPQ
200
ALFPSPDKAA
210
PCGPHEATCR
220
SGHCIPKDYV
230
CDGQEDCRDG
240
SDELDCGPAP
250
PCEPNEFPCG
260
NGHCALKLWR
270
CDGDFDCEDR
280
TDEADCPVKR
290
PEDVCGPTQF
300
RCVSTNTCIP
310
ASFHCDEESD
320
CPDRSDEFGC
330
MPPQVVTPPQ
340
ESIQASRGQT
350
VTFTCVAIGV
360
PTPIINWRLN
370
WGHIPSHPRV
380
TVTSEGGRGT
390
LIIRDVKEAD
400
QGAYTCEAMN
410
ARGMVFGIPD
420
GVLELIPQRG
430
PCPDGHFYLE
440
QSASCLPCFC
450
FGVTNVCQSS
460
RRFRDKIRLR
470
FDQPNDFKGV
480
NVTMPSQPGM
490
PPLSSTQLQI
500
DAALQEFQLV
510
DLSRRFLVHD
520
SFWALPEQFL
530
GNKVDSYGGF
540
LHYKVRYELA
550
RGTLEPVQRP
560
DVVLVGAGHR
570
LLSRGHTPTQ
580
PGTLNQRQVQ
590
FSEEHWVHES
600
GRPVQRAEML
610
QVLQSLEAVL
620
IQTVYNAKMA
630
SVGLSDISMD
640
TTVTYATSHG
650
RAHSVEECRC
660
PIGYSGLSCE
670
SCDAHFTRVP
680
GGPYLGTCSG
690
CSCNGHASSC
700
DPVYGHCLNC
710
QHNTEGPQCN
720
KCKAGFFGDA
730
TKGTATACRP
740
CPCPYIDASR
750
RFSDTCFLDT
760
DGQATCDACA
770
PGYTGRRCES
780
CAPGYEGNPI
790
QPGGKCRPTN
800
QQIVRCDERG
810
STGTSGEACR
820
CKNNVVGRLC
830
NECVAGSFHL
840
SARNPDGCLK
850
CFCMGVSRQC
860
TSSSWSRAQV
870
LGASEEPAQF
880
SLTNAAGTHT
890
TSEGISSPTP
900
GELAFSSFHS
910
LLSGPYFWSL
920
PSRFLGDKVT
930
SYGGELRFTV
940
TQRPQPGSVP
950
LHGQPLVVLQ
960
GNNIILEHHT
970
SQEPSPGQPS
980
TFTVPFREQA
990
WQRPDGQPAT
1000
REHLLMALAG
1010
IDTLLIQASY
1020
TQRPAESRVS
1030
GISMDVAVPE
1040
DTGQDPALEV
1050
EQCTCPPGYR
1060
GPSCQDCDTG
1070
YTRMPSGLYL
1080
GTCERCSCHG
1090
HTEVCEPETG
1100
ACQGCQHHTE
1110
GPRCEQCQPG
1120
YYGDAQRGTP
1130
QDCQPCPCHG
1140
APAAGQATHT
1150
CFLDTDGHPT
1160
CDACSPGHSG
1170
RHCLGFHLWC
1180
PSTSGDDGQV
1190
PEPISCSCDP
1200
QGSISNQCDA
1210
AGQCQCKAQV
1220
EGLTCSHCRP
1230
HHFYLSASNP
1240
DGCLPCFCMG
1250
VTQQCSSSSY
1260
TRHLISTRFA
1270
PGDFQGFALV
1280
NPQRNSRLTG
1290
GFTVEPVPEG
1300
AQLSFGNFAN
1310
LGHESFYWQL
1320
PETYQGDKVA
1330
AYGGKLRYSL
1340
SYTAGAQGSP
1350
LSDPDVQITG
1360
NNIMLVASQP
1370
ALQGPERRSY
1380
EIIFREEFWR
1390
RPDGQPATRE
1400
HLLMALADLD
1410
ELLVRATFSS
1420
MPLAASISAV
1430
SLEVAQPGPS
1440
EGPRAPEVEE
1450
CRCPPGYVGS
1460
SCQDCAPGYT
1470
RTGSGLYLGH
1480
CELCECNGHS
1490
DLCHPETGAC
1500
SQCQHNAAGE
1510
FCELCAPGYY
1520
GDATAGTPED
1530
CQPCACPLTN
1540
PENMFSRTCE
1550
SLGAGGYRCT
1560
ACEPGYTGQY
1570
CEQCAPGYVG
1580
NPNVRGGRCL
1590
PQADQAPLVV
1600
QVQPPRSVVP
1610
QGGPHSLRCQ
1620
VSGSPPHYFY
1630
WSREDGRPLP
1640
SSTQQRHQGS
1650
ELHFPSVQPS
1660
DAGVYICTCR
1670
NLHHANTSRA
1680
ELLVTEAPSK
1690
PITVTVEEQR
1700
SQSVRPGTDV
1710
TFICTAKSKS
1720
PAYTLVWTRL
1730
HNGKLPTRAM
1740
DFNGILTIRN
1750
VQPSDAGTYV
1760
CTGSNMFAMD
1770
QGTATLHVQA
1780
SGTPSAPMAS
1790
IHPPQLTVQP
1800
GQLAEFRCSA
1810
TGNPTPTLEW
1820
TGGPGGQLPQ
1830
KAQILGGILR
1840
LPAVEPSDQA
1850
QYLCHAHSSA
1860
GQHVARAVLH
1870
VHGGNGPRVQ
1880
VSPERTQVHE
1890
GRTVRLYCRA
1900
AGVPSATITW
1910
RKEGGSLPPQ
1920
ARSERTDIAT
1930
LLIPAITTAD
1940
AGFYLCVATS
1950
PAGTAQARIQ
1960
VVVLPASGAS
1970
SPPPVRIESS
1980
SPSVTEGQTL
1990
DLNCVVTGLA
2000
YTQVTWYKRG
2010
GSLPPHAQTH
2020
GSRLRLHQVS
2030
PADSGEYVCR
2040
VVLGSGPLES
2050
SVLVTIEATP
2060
SPGPIPPVRI
2070
ESSSPTVAEG
2080
QTLDLNCVVA
2090
GQAHAQVTWY
2100
KRGGSLPARH
2110
QVRGSRLYIF
2120
QASPADAGEY
2130
VCRASNGVEA
2140
TITVTVTRTQ
2150
GANFAYPPGS
2160
TPIRIEPSSS
2170
HVAEGQTLDL
2180
NCVVPGQAHA
2190
QVTWHKRGGS
2200
LPARHQTHGS
2210
LLRLYQVSPA
2220
DSGEYVCRIV
2230
GGSVPLEASV
2240
LVTIEPADSV
2250
PALGVTPPVR
2260
IESSSSHVAE
2270
GQTLDLNCLV
2280
SGQAHAQVTW
2290
HKRGGSLPAR
2300
HQVHGSRLRL
2310
PQVTPADSGE
2320
YVCRVVSSSG
2330
TQEASVLVTI
2340
QQRLGPSRPQ
2350
SVVYPVRIES
2360
SSDSLANGHT
2370
LDLNCLVASQ
2380
APHTITWYKR
2390
GGSLPSRHQI
2400
VGSRLRIPQV
2410
TPADSGEYVC
2420
HVSNGAGSQE
2430
TSLIVTIQGG
2440
GSSHVPSVSP
2450
PIRIESSSPT
2460
VVEGQTLDLT
2470
CVVAGQPQAT
2480
ITWYKRGGSL
2490
PARHQAHGSH
2500
LRLHQMSVAD
2510
SGEYVCRANN
2520
NIDAQEASIV
2530
VSVSPSTRSP
2540
AVPGGAMPIR
2550
IESSSSHVAE
2560
GQTLDLNCVV
2570
PGQAHAQVTW
2580
HKRGGSLPTH
2590
HQAHGSRLRL
2600
YQLSPADSGE
2610
YVCRVVSSSG
2620
PLEASVLVTI
2630
EASGSGTVLV
2640
PAAGGTPPIR
2650
IETSSSHVAE
2660
GQTLDLKCVV
2670
PGQAHAQVTW
2680
HRRGGSLPAR
2690
HQVHGPLLRL
2700
NQVSPADSGE
2710
YSCRVTGSSG
2720
TQEASVLVTI
2730
EASSPSPIPA
2740
PGLAQPIYIE
2750
ASSSHVTEGQ
2760
TLDLNCVVPG
2770
QAHAQVTWHK
2780
HGGSLPARHQ
2790
THGSRLRLHQ
2800
VSQADSGEYV
2810
CRVVGISGPE
2820
LEASFTVTVP
2830
PSAGSSYRLR
2840
SPVISIDPPS
2850
STVQQGQDAS
2860
FKCLIHDGAA
2870
PISLEWKTRN
2880
QELEDNVHIS
2890
PNGSIITIVG
2900
TRPSNHGAYR
2910
CVASNAYGVA
2920
QSVVTLSVHG
2930
PPTVSVLPEG
2940
PVRVKEGKAI
2950
TLECVSAGEP
2960
RSSARWTRIG
2970
APTNLEQRLH
2980
GLLDSHTLLQ
2990
ISSAKPSDAG
3000
IYVCLAQNAL
3010
GTAQKRVEVI
3020
VDTGIMAPGA
3030
PQVQVEEAEL
3040
TVEAGHTATL
3050
RCSATGSPTP
3060
TIHWSKLRSP
3070
LPWQHQLEGD
3080
TLIIPRVAQQ
3090
DSGQYICNAT
3100
SPAGHAEATI
3110
ALHVESPPYA
3120
TTVPEHASVR
3130
AGETVHLQCL
3140
AHGTPPLTFQ
3150
WSRVGGNLPS
3160
RVTARKEMLL
3170
FEPAAPEDSG
3180
RYRCRVTNKV
3190
GSAEAFAQVL
3200
VQGPSGSLPA
3210
TPHPAGATPA
3220
VQVTPQLETK
3230
SIGASVEFHC
3240
IVPSDQGTQL
3250
RWVKEGGQLP
3260
PGHSVHDGVL
3270
RIQNLDQSCQ
3280
GTYVCQAYGP
3290
WGQAQASAQL
3300
VVQALPSVLI
3310
NIRTSVQTVV
3320
VGHSVEFECL
3330
ALGDPKPQVT
3340
WSKVGGPLRP
3350
GIVQTGGIVR
3360
IAHVELADAG
3370
QYRCTATNAA
3380
GTTQSHVLLL
3390
VQALPQISTP
3400
PEVRVPAGSA
3410
AVFPCMASGY
3420
PTPDISWSKL
3430
DGNLPPDSRL
3440
ENNMLLLPSV
3450
RPQDAGTYVC
3460
TATNRQGKVK
3470
AFAHLQVPER
3480
VVPYFTQTPH
3490
SFLPLPTIKD
3500
AYRKFEIKIT
3510
FRPDSADGML
3520
LYNGQKRIPG
3530
SPTNLANRQP
3540
DFISFGLVGG
3550
RPEFRFDAGS
3560
GMATIRHPTP
3570
LALGQFHTVT
3580
LLRSLTQGSL
3590
IVGSLTPVNG
3600
TSQGKFQGLD
3610
LNEELYLGGY
3620
PDYGAIPKAG
3630
LSSGFVGCVR
3640
ELRIQGEEIV
3650
FHDLNLTAHG
3660
ISHCPTCRDR
3670
PCQNGGHCQD
3680
SESSSYVCMC
3690
PAGFTGSRCE
3700
HSQALHCHPE
3710
ACGPDATCVN
3720
RPDGRGYTCR
3730
CHLGRSGRRC
3740
EEGVTVTTPS
3750
MSGTGSYLAL
3760
PALTNTHHEL
3770
RLDVEFKPLA
3780
PDGILVFSGG
3790
QSGPVEDFVS
3800
LAMVGGHLEF
3810
RYELGSGLAI
3820
LRSSEPLALG
3830
RWHHVSAERF
3840
NKDGSLRVNG
3850
GRPVLRSSPG
3860
KSQGLNLHTL
3870
LYLGGVEPSV
3880
QLPPATNVSA
3890
HFHGCIGEVS
3900
VNGKRLDLTY
3910
SFLGSRGIGQ
3920
CYDSSPCERQ
3930
PCQNGATCMP
3940
AGEYEFQCLC
3950
RDGFKGDLCE
3960
HEENPCQLHE
3970
PCLHGGTCQG
3980
TRCLCPPGFS
3990
GPRCQQGSVH
4000
GIAESDWHLE
4010
GSGGNDAPGQ
4020
YGAYFYDDGF
4030
LALPGRVFSR
4040
SLPEVPETIE
4050
LEVRTSTASG
4060
LLLWQGVEVG
4070
ESGRGKDFIS
4080
LGLQDGHLVF
4090
SYQLGSGEAR
4100
LVSEDPINDG
4110
EWHRVTALRE
4120
GRRGSIQVDG
4130
EELVSGQSPG
4140
PNVAVNTKGS
4150
VYIGGAPDVA
4160
ALTGGRFSSG
4170
ITGCIKNLVL
4180
HSARPGALPP
4190
QPLDLQHRAQ
4200
AGANMRPCPS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0005796 | Golgi lumen |
| Molecular Function | GO:0005509 | calcium ion binding |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0030154 | cell differentiation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.