Search Results

Overview

Uniprot ID	A0A5G2QD12
Protein Name	Pre-mRNA-processing factor 6
Gene Name	PRPF6
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
429	KKARLLLKSVRETNP
866	EAYNQGLKKCPHSTP

Function

Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation

Protein Sequence

10 MHRVHAVSRA 20 APAQGLRFPR 30 VQTANRGLIE 40 GDTARPPAAT 50 RAGAPRACAY 60 RVSVSESRSR 70 RKRAEVAFRE 80 LPVGAAEVGG 90 DLSVRALCFR 100 GAGDAGARAL 110 PAAALRSSVV 120 FGLRPQPPSF 130 PFPAVGVTAA 140 MNKKKKPFLG 150 MPAPLGYVPG 160 LGRGATGFTT 170 RSDIGPARDA 180 NDPVDDRHAP 190 PGKRTVGDQM 200 KKSQAADDDD 210 EDLNDTNYDE 220 FNGYAGSLFS 230 SGPYEKDDEE 240 ADAIYAALDK 250 RMDERRKERR 260 EQREKEEIEK 270 YRMERPKIQQ 280 QFSDLKRKLA 290 EVTEEEWLSI 300 PEVGDARNKR 310 QRNPRYEKLT 320 PVPDSFFAKH 330 LQTGENHTSV 340 DPRQTQFGGL 350 NTPYPGGLNT 360 PYPGGMTPGL 370 MTPGTGELDM 380 RKIGQARNTL 390 MDMRLSQVSD 400 SVSGQTVVDP 410 KGYLTDLNSM 420 IPTHGGDIND 430 IKKARLLLKS 440 VRETNPHHPP 450 AWIASARLEE 460 VTGKLQVARN 470 LIMKGTEMCP 480 KSEDVWLEAA 490 RLQPGDTAKA 500 VVAQAVRHLP 510 QSVRIYIRAA 520 ELETDIRAKK 530 RVLRKALEHV 540 PNSVRLWKAA 550 VELEEPEDAR 560 IMLSRAVECC 570 PTSVELWLAL 580 ARLETYENAR 590 KVLNKARENI 600 PTDRHIWITA 610 AKLEEANGNT 620 QMVEKIIDRA 630 ITSLRANGVE 640 INREQWIQDA 650 EECDKAGSVA 660 TCQAVMRAVI 670 GIGIEEEDRK 680 HTWMEDADSC 690 VAHNALECAR 700 AIYAYALQVF 710 PSKKSVWLRA 720 AYFEKNHGTR 730 YYERARRLLA 740 KARSSAPTAR 750 VSRAAGTRSW 760 LGALSFAVQS 770 CVWPGPFQGA 780 GARLQQRVRA 790 AGWTARGVSR 800 GRARPGRCCL 810 TPSPQVFMKS 820 VKLEWVLGNL 830 AAAQELCEEA 840 LKHYEDFPKL 850 WMMKGQIEEQ 860 EELMEKAREA 870 YNQGLKKCPH 880 STPLWLLLSR 890 LEEKIGQLTR 900 ARAILEKSRL 910 KNPKNPGLWL 920 ESVRLEYRAG 930 LKNIASTLMA 940 KALQECPSSG 950 VLWSEAIFLE 960 ARPQRKTKSV 970 DALKKCEHDP 980 HVLLAVAKLF 990 WSERKITKAR 1000 EWFHRTVKID 1010 SDLGDAWAFF 1020 YKFELQHGTE 1030 EQREEVRRRC 1040 ENAEPRHGEL 1050 WCATSKDITN 1060 WQRKIGEILV 1070 LVAARIRNPF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Biological Process	GO:0000398	mRNA splicing, via spliceosome

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.