Search Results
Overview
| Uniprot ID | A0A5G2QD80 |
|---|---|
| Protein Name | Dynactin subunit 2 |
| Gene Name | DCTN2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 227 | DKFSQAAKVAELEKR |
| 233 | AKVAELEKRLTELEA |
| 301 | VNEIAKHKASVEDAD |
Function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (PubMed:25814576, PubMed:29420470, PubMed:33734450, PubMed:36071160). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity)
Protein Sequence
10
MADPKYADLP
20
GIARNEPDVY
30
ETSDLPEDDQ
40
AEFDAELEEL
50
TSTSVEHIIV
60
NPNAAYDKFK
70
DKRVGTKGLD
80
FSDRIGKTKR
90
TGYESGEYEM
100
LGEGLGVKET
110
PQQKYQRLLH
120
EVQELTTEVE
130
KIKMTVKESA
140
TEEKLTPVVL
150
AKQLAALKQQ
160
LVASHLEKLL
170
GPDAAINLTD
180
PDGALAKRLL
190
LQLEATKNTK
200
GAGSGGKTTS
210
GSPPDSSLVT
220
YELHSRPEQD
230
KFSQAAKVAE
240
LEKRLTELEA
250
TVRCDQDAQN
260
PLSAGLQGAC
270
LMETVELLQA
280
KVSALDLAVL
290
DQVEARLQSV
300
LGKVNEIAKH
310
KASVEDADTQ
320
SKVHQLYETI
330
QRWSPIASTL
340
PELVQRLVTI
350
KQLHEQAMQF
360
GQLLTHLDTT
370
QQMIACSLKD
380
NATLLTQVQT
390
TMRENLSTVE
400
GNFANIDERM
KKLGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005869 | dynactin complex |
| Cellular Component | GO:0030286 | dynein complex |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005874 | microtubule |
| Biological Process | GO:0007017 | microtubule-based process |
| Biological Process | GO:0007052 | mitotic spindle organization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.