Search Results
Overview
| Uniprot ID | A0A5G2QDB8 |
|---|---|
| Protein Name | Thioredoxin reductase 1, cytoplasmic |
| Gene Name | TXNRD1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | NVGCIPKKLMHQAAL |
| 186 | TNNKGKEKIYSAEKF |
| 192 | EKIYSAEKFLIATGE |
| 426 | DNNKCYAKIVCNIKD |
| 432 | AKIVCNIKDNERVVG |
Function
Reduces disulfide protein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. A selenocysteine residue at the C-terminal active site is essential for catalysis. Also has reductase activity on hydrogen peroxide (H2O2)
Protein Sequence
10
INPVICTLPT
20
SGGRRTPLSQ
30
KIGNSVLRRL
40
CKQGCHSPHT
50
HTLQHMEFTD
60
QGSDPSSSLD
70
LSHSCSNTRL
80
ARDRTCVPAL
90
SRHYRSPCLG
100
GTCVNVGCIP
110
KKLMHQAALL
120
GQALRDSRNY
130
GWNVEETIKH
140
DWERMTEAVQ
150
NHIGSLNWGY
160
RVALREKKVT
170
YENAYGQFVG
180
PHRIKVIATN
190
NKGKEKIYSA
200
EKFLIATGER
210
PRYLGIPGDK
220
EYCISSDDLF
230
SLPYCPGKTL
240
VVGASYVALE
250
CAGFLAGIGL
260
DVTVMVRSIL
270
LRGFDQDMAN
280
KIGEHMEEHG
290
VKFIRQFVPI
300
KVSGAACKFV
310
LLAIGRDACT
320
RNIEKALLFL
330
LKYYFKQTNV
340
PYVYAIGDIL
350
EGKPELTPVA
360
IQAGRLLAQR
370
LYGGSTCDYE
380
NVPTTVFTPL
390
EYGACGLSEE
400
KAVEKFGEEN
410
IEIYHSYFWP
420
LEWTIPSRDN
430
NKCYAKIVCN
440
IKDNERVVGF
450
HILGPNAGEV
460
TQGFAAALKC
470
GLTKDQLDST
480
IGIHPVCAEV
490
GHLPLMGQHP
500
LTHGANLGLC
S
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0050137 | NADPH peroxidase activity |
| Molecular Function | GO:0004791 | thioredoxin-disulfide reductase (NADPH) activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.