Overview
| Uniprot ID | A0A5G2QDG4 |
|---|
| Protein Name | Toll-interacting protein |
|---|
| Gene Name | TOLLIP |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 66 |
VVQAKLAKNYGVTRM |
Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates. In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P)
Protein Sequence
10
LCAVPSPQFG
20
PVYLGELPQD
30
FLRITPTQQQ
40
QQIQLDAQAA
50
QQLQFGGTLG
60
TVGRLSITVV
70
QAKLAKNYGV
80
TRMDPYCRLR
90
LGYAVYETPT
100
AHNGAKNPRW
110
NKVIQCTVPP
120
VRAARAFSMD
130
DRIAWTHVTI
140
PESLKQGKVE
150
DEWYSLSGRQ
160
GDDKEGMVNL
170
VMSYTSLPAA
180
VVMPPQPVVL
190
MPTVYQQGVG
200
YVPLAGVPAV
210
CGPGVVPVAL
220
PPAVSAQPRC
230
SEEDLKAMQD
240
MFPNVDREVI
250
RSVLEAQRGS
260
KDAAINSLLQ
MGEES
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Molecular Function |
GO:0043130 |
ubiquitin binding |
| Biological Process |
GO:0006914 |
autophagy |
| Biological Process |
GO:0006954 |
inflammatory response |
| Biological Process |
GO:0045087 |
innate immune response |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.