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Overview

Uniprot IDA0A5G2QE77
Protein NameMitogen-activated protein kinase kinase kinase kinase
Gene NameMAP4K5
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
171 KITATIAKRKSFIGT

Function

Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway

Protein Sequence

10 MEAPLRPAAD 20 ILRRNPQQDY 30 ELVQRVGSGT 40 YGDVYKARNI 50 HTGELAAVKI 60 IKLEPGDDFS 70 LIQQEIFMVK 80 ECKHCNIVAY 90 FGSYLSREKL 100 WICMEYCGGG 110 SLQDIYHVTG 120 PLSELQIAYV 130 CRETLQGLAY 140 LHTKGKMHRD 150 IKGANILLTD 160 HGDVKLADFG 170 VAAKITATIA 180 KRKSFIGTPY 190 WMAPEVAAVE 200 KNGGYNQLCD 210 IWAVGITAIE 220 LGELQPPMFD 230 LHPMRALFLM 240 SKSNFQPPKL 250 KDKTKWSSTF 260 HNFVKIALTK 270 NPKKRPTAER 280 LLTHTFVGQP 290 GLSRALAVEL 300 LDKVNNPDNH 310 THYTEGDDDD 320 FEPHAIIRHT 330 IRSTNRNARA 340 ERTASEINFD 350 KLQFEPPLRK 360 ETEARDEMGL 370 SSDPNFLLRW 380 NPFVDGANTG 390 KSTSKRAVPP 400 PLPPKPRINS 410 YPEDNLPEEE 420 KSSTVKRCPD 430 SENRAPQVLR 440 RQSSPSCGPV 450 AETSAIGNGD 460 GISKLISENT 470 EGSAQAPQLP 480 RKKDKRDFPK 490 PVINGLPPTP 500 KVLMGACFSK 510 VFDGCPLKIN 520 CATSWIHPDT 530 KDQYIIFGTE 540 DGIYTLNLNE 550 LHEATMEQLF 560 PRKCTWLYVI 570 NNTLMSLSEG 580 KTFQLYSHNL 590 IALFEQAKKP 600 GLAAHIQTHR 610 FPDRILPRKF 620 ALTTKIPDTK 630 GCHKCCIVRN 640 PYTGHKYLCG 650 ALQSGIVLLQ 660 WYEPMQKFML 670 IKHFDFPLPS 680 PLNVFEMLVI 690 PEQEYPMVCV 700 AISKGTEPNQ 710 VVQFETINLN 720 SASSWFTEIG 730 AGSQQLDSIH 740 VTQLERDTVL 750 VCLDKFVKIV 760 NLQGKLKSSK 770 KLASELSFDF 780 RIESVVCLQD 790 SVLAFWKHGM 800 QGKSFKSDEV 810 TQEISDETRV 820 FRLLGSDRVV 830 VLESRPTENP 840 TAHSNLYILA GHENSY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0008349 MAP kinase kinase kinase kinase activity
Molecular Function GO:0106310 protein serine kinase activity
Biological Process GO:0035556 intracellular signal transduction

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.