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Overview

Uniprot ID	A0A5G2QEA3
Protein Name	Reticulon
Gene Name	RTN1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
644	SVLQAVQKTDEGHPF

Function

Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity

Protein Sequence

10 MAAPPDSQDE 20 LLPLTSPGSQ 30 WLGDRGEGED 40 EAVTPKGAQP 50 APQAGEPGSG 60 LGAGAREASQ 70 LELGSGPARP 80 PPVAMETAST 90 GMADVSRATD 100 HTFATAARDG 110 GGVCYTSLIS 120 DICYPPREDS 130 TYFTGILQKE 140 NGHIATSESP 150 EEVRTTRPSF 160 PDVPVTEPRG 170 FFSSDSGIEM 180 TPAESTKVSK 190 ILADPIDQMK 200 AEACKYIDIT 210 RPEEVRDQEQ 220 CHPKAEEKDL 230 DLKNKDTEIS 240 DQSEEAREAE 250 KPTPVEGKIL 260 KDHLFEESTF 270 ALYVDDISEE 280 QHSAPVVTAP 290 VKITLTEIEP 300 SVDTATPEKT 310 PEKQDICLKP 320 SPDTVPTVTV 330 SEPEDDSPGS 340 VTPPSSGTEP 350 SAAESQGKCS 360 ISEDELITAI 370 KEAKGLSYET 380 TESPRSAGQV 390 VDRPEAKARS 400 GLPTIPSPLD 410 HEASSAESGD 420 SEIELVSEDP 430 LAAEDALPSG 440 YVTFGHVGGP 450 PPSPASPSIQ 460 YSILREEREA 470 ELDSELIIES 480 CDASSASEES 490 PKREQDSPLM 500 KPGALDAIRE 510 EPGARAEEHA 520 PSQRGLVEFP 530 SAIPQTGPKL 540 PPGDGAPASE 550 EPSLPPKPVE 560 TASSDQSSPA 570 TGVPGPLGPG 580 VAPPLLFLNK 590 QKAIDLLYWR 600 DIKQTGIVFG 610 SFLLLLFSLT 620 QFSVVSVVAY 630 LALAALSATI 640 SFRIYKSVLQ 650 AVQKTDEGHP 660 FKAYLELEIT 670 LSQEQIQKYT 680 DCLQFYVNST 690 LKELRRLFLV 700 QDLVDSLKFA 710 VLMWLLTYVG 720 ALFNGLTLLL 730 MAVVSMFTLP 740 VVYVKHQAQI 750 DQYLGLVRTH 760 INAVVIKIPV ISSYS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005789	endoplasmic reticulum membrane

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.