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Overview

Uniprot ID	A0A5G2QF61
Protein Name	Melanoma inhibitory activity protein 2
Gene Name	MIA2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
855	VEQVLCDKENQIKSL

Function

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum. Thereby, may play a role in cholesterol and triglyceride homeostasis. Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites

Protein Sequence

10 MAELGIHRIL 20 LLVISLTKCL 30 EGTKRLADFK 40 KCGDLECETL 50 ISRVLAIRDY 60 RGPDCRYLNF 70 TKGEEISVYI 80 KLAGEKEDLW 90 AGSKGKDFGY 100 FPRDAVQIEE 110 VFISEEVQIS 120 TKESDFFCLL 130 GISYTFENED 140 IELNIDHSDN 150 IYLYEEDEDP 160 KSNVYESDFQ 170 IEPGFFSTSE 180 GTLFEDQFPA 190 SEAPEAIRST 200 SESKDWEAAE 210 VRSVEEHPLP 220 EVDHVPPSSA 230 VPEVKGWFGF 240 RKDQAEGETF 250 ESVIEPLQES 260 SLLSRKIAVE 270 DENDPEKLNN 280 DEPQTEHKQE 290 PESEVDSMPT 300 KQSELVSESE 310 HYPQDTGWFG 320 GRFTSYFGFR 330 GEDTGLELLS 340 KESNPPLQDV 350 PNSISSEEES 360 TVPCTETLTE 370 KEDTLTNDSS 380 ILKPRWFEFG 390 FAMLGIAYAN 400 EDKIISDDGK 410 NEESGGEDKH 420 GPPPTSEFDP 430 GEEQELKIMK 440 IVETESQIGK 450 EGALEKTDDS 460 DTLPYFKKFL 470 GNFENSWNFK 480 NIPKETELPF 490 PKKTLDENNV 500 GENDETEEFS 510 LENYPTDNTE 520 DMTLESRYSQ 530 SDMNSKIELP 540 MIIHEEVHFK 550 TLSSENNDEN 560 SKTSLDTERS 570 TMVEIDTSVE 580 NTLPNSQIFS 590 TDYSLSSQNY 600 LDQKEDASVG 610 QILKYLFQID 620 VFDFLNPAFS 630 PIVILTGRVV 640 AALPEDMNFH 650 GFPWEVVICA 660 TIVGLFAVVL 670 FLWRSFRSVR 680 REKKLAAELS 690 ALIEEKCKLL 700 EKFSLVQKEY 710 EGLESSLKDA 720 SFEKESTEAQ 730 SLEAFCGKLI 740 NSQSELEDEI 750 LFLEKELREE 760 KSKHSEQDEL 770 MVDISKRIQS 780 LEDESKSLKS 790 QVSEAKTTFK 800 IFQMNEERLK 810 ISIKDALSEN 820 SQLQESQKQL 830 LQEAEEWRER 840 VNELNKQKMT 850 FEDSRAHVEQ 860 VLCDKENQIK 870 SLTERLLKMK 880 DWSAVLGEDI 890 TNDDNLDLEM 900 KNDSENDTLP 910 KGTLKKLIHA 920 AKLKASLKTL 930 EGERNQIYTQ 940 LSEVDKTKED 950 LTECIENLQT 960 EQASLQSENT 970 QFENEIQKLQ 980 QKLKVMTELY 990 QENEMTLHRK 1000 LTVEENYRLE 1010 KEEKLSKADE 1020 KISHAVEELE 1030 TYRKRARDLE 1040 EELERTIHSY 1050 QGQSISHEKK 1060 AHDNWVSVKF 1070 SKFLLSDCSF 1080 HNLNDEFKRL 1090 TETELKFELL 1100 EKDPYALDVP 1110 NTAFGRGSRG 1120 PGNPLDHPIT 1130 NERGDSSADW 1140 LIDPHRAPSD 1150 TGSLSPPWEQ 1160 DRRMMIPPSG 1170 QPYPDPVFPP 1180 QRQDRFYSNS 1190 GRLSGPAELR 1200 SFNMPSLDKV 1210 DGPVSSEMES 1220 NRTDGKDDLG 1230 NLNVPDSSLP 1240 NESEATGPGF 1250 VPPPRPPVRG 1260 PLFPLDARGP 1270 FLRRGPPFPP 1280 PPPGSMYAAP 1290 RDYFPPRDFP 1300 GPPPPPFAMR 1310 SVYPPRGFPH 1320 YLPPRAGFFP 1330 PPPHPESRSE 1340 FPAGLIPPSN 1350 EPTTEHPEPQ QET

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005789	endoplasmic reticulum membrane

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.