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Overview

Uniprot IDA0A5G2QF88
Protein NameAP-3 complex subunit beta
Gene NameAP3B1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
337 SEVGIISKPLVRLLR

Function

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals

Protein Sequence

10 MSSNSFAYNE 20 QSGGGEATEL 30 GQEATSTISP 40 SGAFGLFSSD 50 MKKNEDLKQM 60 LESNKDSAKL 70 DAMKRIVGMI 80 AKGKNASELF 90 PAVVKNVASK 100 NIEIKKLVYV 110 YLVRYAEEQQ 120 DLALLSISTF 130 QRALKDPNQL 140 IRASALRVLS 150 SIRVPIIVPI 160 MMLAIKEASA 170 DLSPYVRKNA 180 AHAIQKLYSL 190 DPEQKEMLIE 200 IIEKLLKDKS 210 TLVAGSVVMA 220 FEEVCPDRID 230 LIHKNYRKLC 240 NLLVDVEEWG 250 QVVIIHMLTR 260 YARTQFVSPW 270 KEDDGLEDNE 280 KDFYDSDEEQ 290 KEKSDKRKKA 300 YTMDPDHRLL 310 IRNTKPLLQS 320 RNAAVVMAVA 330 QLYWHIAPKS 340 EVGIISKPLV 350 RLLRSNREVQ 360 YIVLQNIATM 370 SIQRKGMFEP 380 YLKSFYVRST 390 DPTMIKILKL 400 EILTNLANEA 410 NISTLLREFQ 420 TYVKSQDKQF 430 AAATIQTIGR 440 CATNISEVTD 450 TCLNGLVCLL 460 SNRDEIVVAE 470 SVVVIKKLLQ 480 MQPIQHGEII 490 KHMAKLLDSI 500 TVPVARASIL 510 WLIGENCERV 520 PIIAPDVLRK 530 MAKSFTSEDD 540 LVKLQILNLG 550 AKLYLTNSRQ 560 TKLLTQYILN 570 LGKYDQNYDI 580 RDRTRFIRQL 590 IVPNEKSGAL 600 SKYAKKIFLA 610 QKPAPLLESP 620 FKDRDHFQLG 630 TLSHTLNTKA 640 TGYLELSNWP 650 EVAPDPSVRN 660 VEVIELAKEW 670 TPAGKAKKEK 680 PDKKFYSESE 690 EEEDSSESSS 700 DSESESGSES 710 GEQDEEGDSS 720 EDSSEDSSEH 730 QSESGSESEA 740 ENKRAGQKSS 750 RTKGKRDSED 760 VDKENENSKT 770 SDSSDAESSS 780 IEGSSSGSES 790 ESVSESESES 800 RKVTKEKGKK 810 PKQDGNPLTK 820 DVSLLDLDDS 830 DSNHASVNPV 840 STPVALPVPA 850 LSPSLIADLE 860 GLNLGLKTIF 870 TNSPFLSFSN 880 VGKGLAAHYS 890 FPRQPCIFGD 900 KMVSVQITLN 910 NTTDRKIENI 920 HIGEKKLPMG 930 MQMHVFNPIG 940 SLEPGGSITV 950 SMGIDFCDST 960 QTASLQLCTK 970 DDCFSVNIQP 980 PVGELLLPVA 990 MSEKDFKKEQ 1000 GRLTGMNETS 1010 TLIIAAPQNF 1020 TSSVILQKVV 1030 NVANLGVVPS GQDNVHR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030123 AP-3 adaptor complex
Cellular Component GO:0030665 clathrin-coated vesicle membrane
Cellular Component GO:0005794 Golgi apparatus
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.