Overview
| Uniprot ID | A0A5G2QFC4 |
|---|
| Protein Name | Acetyltransferase component of pyruvate dehydrogenase complex |
|---|
| Gene Name | DLAT |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 225 |
PATPAGPKGRLFVSP |
| 235 |
LFVSPLAKKLASEKG |
| 249 |
GIDLTQIKGTGPDGR |
| 260 |
PDGRIIKKDIDSFVP |
| 346 |
KMLEGRSKISVNDFI |
Function
The pyruvate dehydrogenase (PDH) complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3);. Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acetyl groups from acetyl-lipoyl moiety generated by the pyruvate dehydrogenase, leading to acetyl-CoA formation
Protein Sequence
10
MWRVCARRAQ
20
NAAPRAGFGA
30
RWTALREEPG
40
APCAAPRAGS
50
VPARCSSTTR
60
GYGRSRALCG
70
WSASSWATPQ
80
NRILLQLWGS
90
PNRRWYSLPP
100
HQKVPLPSLS
110
PTMQAGTIAR
120
WEKKEGDKIN
130
EGELIAEVET
140
DKATVGFESL
150
EECYLAKILI
160
PEGTRDVPLG
170
TPLCIIVEKE
180
ADIPAFADYR
190
PTEVTDLKPP
200
APPPTPSPVT
210
PVPPAPQPVA
220
PTPAATRPAT
230
PAGPKGRLFV
240
SPLAKKLASE
250
KGIDLTQIKG
260
TGPDGRIIKK
270
DIDSFVPTKA
280
APPPAAAVPP
290
PSPGVAPVPT
300
GVFTDIPISN
310
IRRVIAQRLM
320
QSKQTIPHYY
330
LSVDVNMGEV
340
LLVRKELNKM
350
LEGRSKISVN
360
DFIIKASALA
370
CLKVPEANSS
380
WLDTVIRQNH
390
VVDISVAVST
400
PAGLITPIVF
410
NAHIKGLETI
420
ANDVVSLATK
430
AREGKLQPHE
440
FQGGTFTISN
450
LGMFGIKNFS
460
AIINPPQACI
470
LAVGASEDRL
480
FPADNEKGFD
490
VASMMSVTLS
500
CDHRVVDGAV
510
GAQWLAEFRK
520
YLEKPITMLL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0045254 |
pyruvate dehydrogenase complex |
| Molecular Function |
GO:0004742 |
dihydrolipoyllysine-residue acetyltransferase activity |
| Biological Process |
GO:0006006 |
glucose metabolic process |
| Biological Process |
GO:0006086 |
pyruvate decarboxylation to acetyl-CoA |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.