Search Results
Overview
| Uniprot ID | A0A5G2QFU4 |
|---|---|
| Protein Name | Eukaryotic translation initiation factor 2A |
| Gene Name | EIF2A |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | AVYVPGSKGAPSFVR |
| 264 | VWDVKNYKLISKPVA |
Function
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner
Protein Sequence
10
ELPYAAGAAL
20
KTSKDGAAGI
30
PNLQLYDMKT
40
GTCLKSFIQK
50
KMQNWCPSWS
60
EDETLCARNV
70
NNEVHFFENN
80
NFNTIANKLH
90
LKKINDFVLS
100
PGPQPYKVAV
110
YVPGSKGAPS
120
FVRLYQYPNF
130
DGPHAALANK
140
SFFKADKVTM
150
LWNKKATAVL
160
VIASTEVDKT
170
GASYYGEQTL
180
HYIATNGESA
190
VVQLPKNGPI
200
YDVVWNSSST
210
EFCAVYGFMP
220
AKATIFNLKC
230
DPVFDFGTGP
240
RNAAYYSPHG
250
HILVLAGFGN
260
LRGQMEVWDV
270
KNYKLISKPV
280
ASDSTYFAWC
290
PDGEHILTAT
300
CAPRLRVNNG
310
YKIWHYTGSV
320
LHKYDVPSNA
330
ELWQVSWQPF
340
LDGIFPEKSI
350
TYQAVPSDVP
360
SEEPKVATAY
370
RPPALRNKPV
380
TNSKLHEEEP
390
PQNMKPQPGN
400
EKPLSKTALK
410
NQRKHEAKKA
420
AKQEARSDKS
430
PDMAPSPAPQ
440
NTPRNTVSHS
450
TSGDPEIDKK
460
IKNLKKKLKA
470
IEQLKEQAAT
480
GKQLEKNQVC
490
SAFFFFFFLG
500
PHLQHMEVPS
LGVESEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0043022 | ribosome binding |
| Molecular Function | GO:0003743 | translation initiation factor activity |
| Molecular Function | GO:0000049 | tRNA binding |
| Biological Process | GO:0006417 | regulation of translation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.