Overview
| Uniprot ID | A0A5G2QG21 |
|---|
| Protein Name | Actin-related protein 2/3 complex subunit 4 |
|---|
| Gene Name | TTLL3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 43 |
QVVERHNKPEVEVRS |
| 52 |
EVEVRSSKELLLQPV |
| 68 |
ISRNEKEKVLIEGSI |
| 85 |
VRVSIAVKQADEIEK |
| 92 |
KQADEIEKILCHKFM |
| 97 |
IEKILCHKFMRFMMM |
Function
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)
Protein Sequence
10
TCVLVDASQT
20
ATLRPYLSAV
30
RATLQAALCL
40
ENFSSQVVER
50
HNKPEVEVRS
60
SKELLLQPVT
70
ISRNEKEKVL
80
IEGSINSVRV
90
SIAVKQADEI
100
EKILCHKFMR
110
FMMMRAENFF
120
ILRRKPVEGY
130
DISFLITNFH
140
TEQMYKHKLV
150
DFVIHFMEEI
160
DKEISEMKLS
170
VNARARIVAE
180
EFLKNVSEGP
190
SCFPSRSRKT
SGLC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005885 |
Arp2/3 protein complex |
| Molecular Function |
GO:0003779 |
actin binding |
| Biological Process |
GO:0030041 |
actin filament polymerization |
| Biological Process |
GO:0034314 |
Arp2/3 complex-mediated actin nucleation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.