Search Results
Overview
| Uniprot ID | A0A5G2QGH6 |
|---|---|
| Protein Name | S-methyl-5'-thioadenosine phosphorylase |
| Gene Name | MTAP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 112 | ILEGRTEKYVDTPFG |
| 129 | SDALILGKIKNVDCV |
| 131 | ALILGKIKNVDCVLL |
| 199 | QFIDRTTKRPQTFYD |
| 237 | EVLIETAKKLGLRCH |
| 246 | LGLRCHSKGTMITIE |
| 321 | DRVLKTLKENANKAK |
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates
Protein Sequence
10
MEKNNGKPER
20
SAKGAGRGNL
30
QMRRGVAGES
40
PHQQPIQLSR
50
EGRGGARAAP
60
GPSLLSPALS
70
SGTRSAPAIP
80
ARLLLLPRTD
90
MALSAAAAAV
100
KIGIIGGTGL
110
DDPEILEGRT
120
EKYVDTPFGK
130
PSDALILGKI
140
KNVDCVLLAR
150
HGRQHTIMPS
160
KVNYQANIWA
170
LKEEGCTHII
180
VTTACGSLKE
190
EIQPGDFIII
200
DQFIDRTTKR
210
PQTFYDGNHS
220
CARGVCHIPM
230
AEPFCPKTRE
240
VLIETAKKLG
250
LRCHSKGTMI
260
TIEGPRFSSR
270
AESLTFQTWG
280
ADVINMTTVP
290
EVVLAKEAGI
300
CYASIAMATD
310
YDCWKEHEEV
320
VSVDRVLKTL
330
KENANKAKSL
340
LLTTIPQIGS
350
MEWSETLHNL
360
KIGSFSVLVL
NP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0017061 | S-methyl-5-thioadenosine phosphorylase activity |
| Biological Process | GO:0019509 | L-methionine salvage from methylthioadenosine |
| Biological Process | GO:0006166 | purine ribonucleoside salvage |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.