Search Results
Overview
| Uniprot ID | A0A5G2QGU2 |
|---|---|
| Protein Name | Histone deacetylase 2 |
| Gene Name | HDAC2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 284 | LTVKGHAKCVEVVKT |
| 75 | YHSDEYIKFLRSIRP |
| 9 | AYSQGGGKKKVCYYY |
Function
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes
Protein Sequence
10
MAYSQGGGKK
20
KVCYYYDGDI
30
GNYYYGQGHP
40
MKPHRIRMTH
50
NLLLNYGLYR
60
KMEIYRPHKA
70
TAEEMTKYHS
80
DEYIKFLRSI
90
RPDNMSEYSK
100
QMQRFNVGED
110
CPVFDGLFEF
120
CQLSTGGSVA
130
GAVKLNRQQT
140
DMAVNWAGGL
150
HHAKKSEASG
160
FCYVNDIVLA
170
ILELLKYHQR
180
VLYIDIDIHH
190
GDGVEEAFYT
200
TDRVMTVSFH
210
KYGEYFPGTG
220
DLRDIGAGKG
230
KYYAVNFPMR
240
DGIDDESYGQ
250
IFKPIISKVM
260
EMYQPSAVVL
270
QCGADSLSGD
280
RLGCFNLTVK
290
GHAKCVEVVK
300
TFNLPLLMLG
310
GGGYTIRNVA
320
RCWTYETAVA
330
LDCEIPNELP
340
YNDYFEYFGP
350
DFKLHISPSN
360
MTNQNTPEYM
370
EKIKQRLFEN
380
LRMLPHAPGV
390
QMQAIPEDAV
400
HEDSGDEDGE
410
DPDKRISIRA
420
SDKRIACDEE
430
FSDSEDEGEG
440
GRRNVADHKK
450
GAKKARIEED
460
KKETEDKKAG
470
KCREDKVVLD
PFVACQQS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0141221 | histone deacetylase activity, hydrolytic mechanism |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0160008 | protein decrotonylase activity |
| Molecular Function | GO:0160216 | protein lysine delactylase activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.