Search Results
Overview
| Uniprot ID | A0A5G2QGY3 |
|---|---|
| Protein Name | Gigaxonin |
| Gene Name | GAN |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 455 | WTAICPLKERRFGAV |
Function
Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival
Protein Sequence
10
MAEGSAVSDP
20
HHAARLLRAL
30
SSFREESRFC
40
DAHLVLDGEE
50
IPVQKNILAA
60
ASPYIRTKLN
70
YNPPKDDGST
80
YKIELEGISV
90
MVMREILDYI
100
FSGQIRLNEE
110
TIQDVVQAAD
120
LLLLTDLKTL
130
CCEFLEGCIA
140
AENCIGIRDF
150
ALHYCLHHVH
160
YLATEYLETH
170
FRDVSSTEEF
180
LELSPQKLKE
190
VISLEKLNVG
200
NERYVFEAVI
210
RWIAHDTEIR
220
KVHMKDVMSA
230
LWVSGLDSSY
240
LREQMLSEPL
250
VREIVKECSN
260
IPLSQPQQGE
270
AMLASFKPRG
280
YSECIVTVGG
290
EERVSRKPTA
300
AMRCMCPLYD
310
PNRQLWIELA
320
PLSMPRINHG
330
VLSAEGFLFV
340
FGGQDENKQT
350
LSSGEKYDPD
360
ANTWTALPPM
370
NEARHNFGIV
380
EIDGMLYVLG
390
GEDGEKELIS
400
MECYDTYSKT
410
WTKQPDLTMV
420
RKIGCYAAMK
430
KKIYAMGGGS
440
YGKLFESVEC
450
YDPRTQQWTA
460
ICPLKERRFG
470
AVACGVAMEL
480
YVFGGVRSRE
490
DIQGGEMVTC
500
KSEFYHDEFK
510
RWIYLNDQNL
520
CIPTSSSFVY
530
GAVPIGASIY
540
VIGDLDTGTN
550
YDYVREFKRS
560
TGTWHHTKPL
570
LPSDLRRTGC
580
AALRIANCKL
590
FRLQLQQGLF
RIRVHSP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031463 | Cul3-RING ubiquitin ligase complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Molecular Function | GO:1990756 | ubiquitin-like ligase-substrate adaptor activity |
| Biological Process | GO:0007010 | cytoskeleton organization |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0016567 | protein ubiquitination |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.