Search Results
Overview
| Uniprot ID | A0A5G2QHD4 |
|---|---|
| Protein Name | Replication protein A subunit |
| Gene Name | RPA1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 121 | SKAYGASKIFGKAGA |
| 125 | GASKIFGKAGATSVV |
| 164 | ICARVTNKSQIRTWS |
| 217 | NKVYYFSKGTLKIAN |
| 221 | YFSKGTLKIANKQFT |
| 225 | GTLKIANKQFTAVKN |
| 289 | KNYEDVTKITVKSTN |
| 293 | DVTKITVKSTNREVS |
| 447 | PTQDCNKKVIDQQNG |
| 535 | FTFRIRVKLETYNDE |
| 77 | RFIVNTLKDGRRVVI |
Function
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage
Protein Sequence
10
MANPLSCRLG
20
LLVPGDWAGS
30
LANAWNNPPR
40
YRLLMSDGLN
50
TLSSFMLATQ
60
LNPLVEEERL
70
SSNCICQINR
80
FIVNTLKDGR
90
RVVILMDLEV
100
LKSAEAVGVK
110
IGNPVPYNEG
120
STVSKAYGAS
130
KIFGKAGATS
140
VVNSSGGTQA
150
KVVPIASLTP
160
YQSKWTICAR
170
VTNKSQIRTW
180
SNSRGEGKLF
190
SIELVDESGE
200
IRATAFNEQV
210
DKFFPLIDVN
220
KVYYFSKGTL
230
KIANKQFTAV
240
KNDYEMTFSN
250
ETSVMPCEDG
260
HHLPTVQFDF
270
TGIADLENKS
280
KDSLVDIIGI
290
CKNYEDVTKI
300
TVKSTNREVS
310
KRNIYLMDMS
320
GKVVNATLWG
330
EDADKFDGSR
340
QPVMAIKGAR
350
VSDFGGRSLS
360
ILSSSTVIVN
370
PDIPEAYKLR
380
GWFDSEGQAL
390
DGVSISDLKS
400
GGIGGSNTNW
410
KTLYEVKSEN
420
LGQGDKPDYF
430
SAVATVVYLR
440
KENCMYQACP
450
TQDCNKKVID
460
QQNGLYRCEK
470
CDSEFPNFKY
480
RMILSVNIAD
490
FQENQWVTCF
500
QESAEAILGQ
510
STAYLGELKE
520
KNEQAFEEVF
530
QNANFRSFTF
540
RIRVKLETYN
550
DESRIKGTVM
560
DVKPVDYKEY
570
GRRLIMSIRK
NAAM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000228 | nuclear chromosome |
| Cellular Component | GO:0016605 | PML body |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006310 | DNA recombination |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006260 | DNA replication |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.