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Overview

Uniprot IDA0A5G2QHR5
Protein NameTricarboxylate transport protein, mitochondrial
Gene NameSLC25A1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
501 ILRNEGLKAFYKGTI
505 EGLKAFYKGTIPRLG
534 EVVKLLNKVWKTD**

Function

Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes

Protein Sequence

10 GTPGEQGASG 20 VFSPSCAPLG 30 ARESVSTDPA 40 ALRPRGEWGE 50 GWPGGVAPPS 60 WRGGGVPTST 70 GGGAVGRRGR 80 CLVGPHAAIG 90 WATGPARPQF 100 PAGSGRVGGG 110 ARLGPRGAEL 120 GSDAVAQPRP 130 ITGAAAAVAT 140 EHGSSDPRPP 150 PGPLPRPPWP 160 TPALLRPPRP 170 RPGKPSSHTR 180 GRRSWQVGAR 190 ARRPPTPTPT 200 PPRFRVAPDT 210 GFAVLPGGVR 220 PPARVPGAPG 230 QDRGRGVGPA 240 PRRRAKSGRG 250 RVRRWGGGGV 260 SAWSPCVPAG 270 GLAGGIEICI 280 TFPTEYVKTQ 290 LQLDERSHPP 300 RYRGIGDCVR 310 QTVRSHGVLG 320 LYRGLSSLLY 330 GSIPKAAVRF 340 GTFEFLSNHM 350 RDAQGRLDST 360 RGLLCGLGAG 370 VAEAVVVVCP 380 METIKVKFIH 390 DQTSSNPKYR 400 GFFHGVREIV 410 REQGLKGTYQ 420 GLTATVLKQG 430 SNQAIRFFVM 440 TALRNWYRGD 450 NPNKPMNPLI 460 TGVFGAIAGA 470 ASVFGNTPLD 480 VIKTRMQGLE 490 AHKYRNTWDC 500 GLQILRNEGL 510 KAFYKGTIPR 520 LGRVCLDVAI 530 VFIIYDEVVK LLNKVWKTD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031966 mitochondrial membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0071913 citrate secondary active transmembrane transporter activity
Biological Process GO:0006843 mitochondrial citrate transmembrane transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.