Search Results
Overview
| Uniprot ID | A0A5G2QI12 |
|---|---|
| Protein Name | Protein enabled homolog |
| Gene Name | ENAH |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 22 | VYDDANKKWVPAGGS |
| 460 | RRRRIAEKGSTIETE |
| 52 | TFRVVGRKIQDHQVV |
| 552 | RKELTKLKEELIDAI |
| 66 | VINCAIPKGLKYNQA |
| 69 | CAIPKGLKYNQATQT |
Function
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation
Protein Sequence
10
MSEQSICQAR
20
AAVMVYDDAN
30
KKWVPAGGST
40
GFSRVHIYHH
50
TGNNTFRVVG
60
RKIQDHQVVI
70
NCAIPKGLKY
80
NQATQTFHQW
90
RDARQVYGLN
100
FGSKEDANVF
110
ASAMMHALEV
120
LNSQEAAQSK
130
VTATQESTNL
140
RCIFCGPTLP
150
RQNSQLPAQV
160
QNGPSQEELE
170
IQRRQLQEQQ
180
RQKELERERL
190
ERERMERERL
200
ERERLERERL
210
ERERLEQEQL
220
ERERQERERQ
230
ERQERLERER
240
QERERLERLE
250
RLDRERQERE
260
RQEQLEREQL
270
EWERERRVSS
280
AAAPASVETP
290
LNSVLGDSSA
300
SEPGLQAASQ
310
PAETPAQQGI
320
VLGPPAPPPP
330
PPLPPGPAQA
340
SAILPPPPGP
350
PPPPPLPSSG
360
PPPPPPPPPL
370
PNQAPPPPPP
380
PPAPPLPASG
390
FFSGSMSEDN
400
RPLTGLAAAI
410
AGAKLRKVSR
420
MEDGSFPSGV
430
NAASSKTDTG
440
RGNGPLPLGG
450
SGLMEEMSAL
460
LARRRRIAEK
470
GSTIETEQKE
480
DKNEDSEPQT
490
SKASSTSTPE
500
PTRKPWERTN
510
TMNGSKSPVI
520
SRPKSAPSSQ
530
PSANGVQTEG
540
LDYDRLKQDI
550
LDEMRKELTK
560
LKEELIDAIR
QELSKSNTA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.