Overview
| Uniprot ID | A0A5G2QI19 |
|---|
| Protein Name | Proteasome subunit alpha type |
|---|
| Gene Name | PSMA1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 121 |
LVSLIGSKTQIPTQR |
| 249 |
LEERPQRKAQPAQPA |
| 45 |
GSATVGLKSKTHAVL |
| 47 |
ATVGLKSKTHAVLVA |
| 56 |
HAVLVALKRAQSELA |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Protein Sequence
10
MQLSMVKFRN
20
QYDNDVTVWS
30
PQGRIHQIEY
40
AMEAVKQGSA
50
TVGLKSKTHA
60
VLVALKRAQS
70
ELAAHQKKIL
80
HVDNHIGISI
90
AGLTADARLL
100
CNFMRQECLD
110
SRFVFDRPLP
120
VSRLVSLIGS
130
KTQIPTQRYG
140
RRPYGVGLLI
150
AGYDDMGPHI
160
FQTCPSANYF
170
DCRAMSIGAR
180
SQSARTYLER
190
HMSEFMECNL
200
NELVKHGLRA
210
LRETLPAEQD
220
LTTKNVSIGI
230
VGKDLEFTIY
240
DDDDVSPFLE
250
GLEERPQRKA
260
QPAQPADEPA
EKADEPMEH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0019773 |
proteasome core complex, alpha-subunit complex |
| Molecular Function |
GO:0001530 |
lipopolysaccharide binding |
| Biological Process |
GO:0002862 |
negative regulation of inflammatory response to antigenic stimulus |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0061136 |
regulation of proteasomal protein catabolic process |
| Biological Process |
GO:0006979 |
response to oxidative stress |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.