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Overview

Uniprot IDA0A5G2QIE6
Protein NameDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
Gene NameDLAT
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
352 PATPAGPKGRLFVSP
362 LFVSPLAKKLASEKG
376 GIDLTQIKGTGPDGR
387 PDGRIIKKDIDSFVP
437 RMLEGRSKISVNDFI

Function

The pyruvate dehydrogenase (PDH) complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3);. Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acetyl groups from acetyl-lipoyl moiety generated by the pyruvate dehydrogenase, leading to acetyl-CoA formation

Protein Sequence

10 MWRVCARRAQ 20 NAAPRAGFGA 30 RWTALREEPG 40 APCAAPRAGS 50 VPARCSSTTR 60 GYGRSRALCG 70 WSASSWATPQ 80 NRILLQLWGS 90 PNRRWYSLPP 100 HQKVPLPSLS 110 PTMQAGTIAR 120 WEKKEGDKIN 130 EGELIAEVET 140 DKATVGFESL 150 EECYMAKILV 160 AEGTRDVPVG 170 AIICITVEKP 180 EDIEAFKNYT 190 LDSSAAPAPQ 200 AAPAPTPAAA 210 APAPTPSAQA 220 PGSSYPTHMQ 230 VVLPALSPTM 240 TMGTVQRWEK 250 KVGEKLSEGD 260 LLAEIETDKA 270 TIGFEVQEEG 280 YLAKILIPEG 290 TRDVPLGTPL 300 CIIVEKEADI 310 PAFADYRPTE 320 VTDLKPPAPP 330 PTPSPVTPVP 340 PAPQPVAPTP 350 AATRPATPAG 360 PKGRLFVSPL 370 AKKLASEKGI 380 DLTQIKGTGP 390 DGRIIKKDID 400 SFVPTKAAPP 410 PAAAVPPPSP 420 GVAPVPTGVF 430 TDIPISNIRR 440 MLEGRSKISV 450 NDFIIKASAL 460 ACLKVPEANS 470 SWLDTVIRQN 480 HVVDISVAVS 490 TPAGLITPIV 500 FNAHIKGLET 510 IANDVVSLAT 520 KAREGKLQPH 530 EFQGGTFTIS 540 NLGMFGIKNF 550 SAIINPPQAC 560 ILAVGASEDR 570 LFPADNEKGF 580 DVASMMSVTL 590 SCDHRVVDGA 600 VGAQWLAEFR 610 KYLEKPITML L

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0045254 pyruvate dehydrogenase complex
Molecular Function GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0006086 pyruvate decarboxylation to acetyl-CoA

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.