Search Results
Overview
| Uniprot ID | A0A5G2QIZ1 |
|---|---|
| Protein Name | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial |
| Gene Name | DLST |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 196 | SKPVSAVKPTAAPPV |
| 260 | QDMRARHKEAFLKKH |
| 346 | TISELGEKARKNELA |
| 433 | VTFLRKIKAAVEDPR |
| 59 | FRTTAVCKDDVITVK |
Function
Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A
Protein Sequence
10
MLRRDPRARF
20
LSGNCPLGRR
30
SLPGISLCQG
40
PGYPDSRKIV
50
ISNSSVLNVR
60
FFRTTAVCKD
70
DVITVKTPAF
80
AESVTEGDVR
90
WEKAVGDTVA
100
EDEVVCEIET
110
DKTSVQVPSP
120
ANGVIEALLV
130
PDGGKVEGGT
140
PLFTLRKTGA
150
APAKAKPAEA
160
PAAAAPKAEP
170
AVSAVPPPPA
180
ASIPTQMPPV
190
PSPPQPLTSK
200
PVSAVKPTAA
210
PPVAEPGAVK
220
GLRAEHREKM
230
NRMRQRIAQR
240
LKEAQNTCAM
250
LTTFNEIDMS
260
NIQDMRARHK
270
EAFLKKHNLK
280
LGFMSAFVKA
290
SAFALQEQPV
300
VNAVIDDTTK
310
EVVYRDYIDI
320
SVAVATPRGL
330
VVPVIRNVET
340
MNYADIERTI
350
SELGEKARKN
360
ELAIEDMDGG
370
TFTISNGGVF
380
GSLFGTPIIN
390
PPQSAILGMH
400
AIVDRPVAVG
410
GKVEIRPMMY
420
VALTYDHRLI
430
DGREAVTFLR
440
KIKAAVEDPR
VLLLDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0160167 | oxoadipate dehydrogenase complex |
| Cellular Component | GO:0045252 | oxoglutarate dehydrogenase complex |
| Molecular Function | GO:0004149 | dihydrolipoyllysine-residue succinyltransferase activity |
| Biological Process | GO:0120551 | 2-oxoglutarate decarboxylation to succinyl-CoA |
| Biological Process | GO:0033512 | L-lysine catabolic process to acetyl-CoA via L-saccharopine |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.