Overview
| Uniprot ID | A0A5G2QJ69 |
|---|
| Protein Name | Ras-related protein Rab-18 |
|---|
| Gene Name | RAB18 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 119 |
VDRNEGLKFARKHSM |
| 167 |
ENQNKGVKLTHREEG |
| 29 |
IGVDFKVKTISVDGN |
| 37 |
TISVDGNKAKLAIWD |
| 39 |
SVDGNKAKLAIWDTA |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Also required for maintaining endoplasmic reticulum structure. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration
Protein Sequence
10
ISFSLLLRFT
20
DDTFDPELAA
30
TIGVDFKVKT
40
ISVDGNKAKL
50
AIWDTAGQER
60
FRTLTPSYYR
70
GAQGVILVYD
80
VTRRDTFVKL
90
DNWLNELETY
100
CTRNDIVNML
110
VGNKIDKENR
120
EVDRNEGLKF
130
ARKHSMLFIE
140
ASAKTCDGVQ
150
CAFEELVEKI
160
IQTPGLWESE
170
NQNKGVKLTH
180
REEGQGGGAC
GGYCSVL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0005811 |
lipid droplet |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0005525 |
GTP binding |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.