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Overview

Uniprot ID	A0A5G2QJX3
Protein Name	Zinc finger CCHC domain-containing protein 8
Gene Name	ZCCHC8
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
632	LRIRNLLKNSPRNQQ

Function

Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing. It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function

Protein Sequence

10 MFIHMQVLLS 20 CLLKICLNFC 30 FSGILVNNTK 40 LDGPLLQILF 50 MNNVISKQYH 60 QEIEEFVSNL 70 VKRFEEQQKN 80 DVEKTSFNLL 90 PQPSSVMLQE 100 DHKVEESSDV 110 QNNKEAFSVV 120 GSVLYFTNFC 130 LDKLGQPLLN 140 ENPQLTEGWE 150 IPKYQQVFSH 160 IVSLEGQEIQ 170 VKAKRPKPHC 180 FNCGSEEHQM 190 KDCPMPRNAA 200 RISEKRKEYM 210 DACGETNNQN 220 FQQRYHAEEV 230 EERFGRFKPG 240 VISEELQDAL 250 GVTDKSLPPF 260 IYRMRQLGYP 270 PGWLKEAELE 280 NSGLALYDGK 290 DGADGETEAG 300 EVQQNKSVTY 310 DLSKLVNYPG 320 FNISTPRGIP 330 DEWRMFGSIP 340 MQACQQKDVF 350 ASYLTSNFQA 360 PSVRSNSKRA 370 SSQSSPSSPK 380 KQKKEGSLAA 390 SPADMELDSD 400 AEVPSNEAFQ 410 FQPPLPPGTP 420 PPLPQGTPPP 430 TFTPPLPKGT 440 PPLTPSDSPQ 450 TRAASVTMDE 460 DALTLEELEE 470 QQRRIWAALE 480 QAESVNSDSD 490 IPVDTPLTGN 500 SVASSPCPNE 510 LELPALEEKP 520 SEKQMPDEAE 530 VPDTCTKKSE 540 VEQCSSPDSE 550 AALLDQKEKE 560 ASAQVSCKDA 570 PLGNGSVKSN 580 CAISNGGGSQ 590 KLLHVDTSPA 600 TAPKIHSPIP 610 DMSKFATGIT 620 PFEFENMAES 630 TGMYLRIRNL 640 LKNSPRNQQK NKKTSE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0003676	nucleic acid binding
Molecular Function	GO:0008270	zinc ion binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.