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Overview

Uniprot IDA0A5G2QK83
Protein NameAcetyltransferase component of pyruvate dehydrogenase complex
Gene NameDLAT
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
342 PATPAGPKGRLFVSP
352 LFVSPLAKKLASEKG
366 GIDLTQIKGTGPDGR
377 PDGRIIKKDIDSFVP
463 KMLEGRSKISVNDFI

Function

The pyruvate dehydrogenase (PDH) complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3);. Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acetyl groups from acetyl-lipoyl moiety generated by the pyruvate dehydrogenase, leading to acetyl-CoA formation

Protein Sequence

10 MWRVCARRAQ 20 NAAPRAGFGA 30 RWTALREEPG 40 APCAAPRAGS 50 VPARCSSTTR 60 GYGSSWATPQ 70 NRILLQLWGS 80 PNRRWYSLPP 90 HQKVPLPSLS 100 PTMQAGTIAR 110 WEKKEGDKIN 120 EGELIAEVET 130 DKATVGFESL 140 EECYMAKILV 150 AEGTRDVPVG 160 AIICITVEKP 170 EDIEAFKNYT 180 LDSSAAPAPQ 190 AAPAPTPAAA 200 APAPTPSAQA 210 PGSSYPTHMQ 220 VVLPALSPTM 230 TMGTVQRWEK 240 KVGEKLSEGD 250 LLAEIETDKA 260 TIGFEVQEEG 270 YLAKILIPEG 280 TRDVPLGTPL 290 CIIVEKEADI 300 PAFADYRPTE 310 VTDLKPPAPP 320 PTPSPVTPVP 330 PAPQPVAPTP 340 AATRPATPAG 350 PKGRLFVSPL 360 AKKLASEKGI 370 DLTQIKGTGP 380 DGRIIKKDID 390 SFVPTKAAPP 400 PAAAVPPPSP 410 GVAPVPTGVF 420 TDIPISNIRR 430 VIAQRLMQSK 440 QTIPHYYLSV 450 DVNMGEVLLV 460 RKELNKMLEG 470 RSKISVNDFI 480 IKASALACLK 490 VPEANSSWLD 500 TVIRQNHVVD 510 ISVAVSTPAG 520 LITPIVFNAH 530 IKGLETIAND 540 VVSLATKARE 550 GKLQPHEFQG 560 GTFTISNLGM 570 FGIKNFSAII 580 NPPQACILAV 590 GASEDRLFPA 600 DNEKGFDVAS 610 MMSVTLSCDH 620 RVVDGAVGAQ 630 WLAEFRKYLE KPITMLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0045254 pyruvate dehydrogenase complex
Molecular Function GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0006086 pyruvate decarboxylation to acetyl-CoA

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.