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Overview

Uniprot IDA0A5G2QK84
Protein NameIntegrin alpha-5
Gene NameITGA5
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
910 SSGPQILKCPEAECF
943 LHFRVWAKTFLQREH

Function

Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling

Protein Sequence

10 MGSRTPGSPL 20 QAVQLRWGPR 30 RRSRLLPLLP 40 PPLLLLLLLP 50 PPLRVGGFNL 60 DAEAPAVLSG 70 PPGSFFGFSV 80 EFYRPGTDGV 90 SVLVGAPKAN 100 TSQPGVLQGG 110 AVYLCPWATS 120 PAPCTPIEFD 130 SKGSRILESS 140 PSSLEGDEPV 150 EYKSLQWFGA 160 TVRAHGSSIL 170 ACAPLYSWRT 180 EKEPLNDPVG 190 TCYLSTDNFT 200 RILEYAPCRS 210 DFSSAAGQGY 220 CQGGFSAEFT 230 KTGRVVLGGP 240 GSYFWQGQIL 250 SATQEQISES 260 YYPEYLINPV 270 QGQLQTRQAS 280 SIYDDSYLGE 290 LPGLGNFVAG 300 VPKGNLTYGY 310 VTILNGSDIR 320 SLYNFSGEQM 330 ASYFGYAVAA 340 TDINGDGLDD 350 LLVGAPLLME 360 RTADGRPQEV 370 GRVYIYLQSP 380 AGMEPAPART 390 LTGHDEFGRF 400 GSSLTPLGDL 410 DQDGYNDVAI 420 GATFGGENRQ 430 GAVFIFPGGP 440 EGLASKPSQV 450 LQPLWAAGHT 460 PDFFGSALRG 470 GRDLDGNGYP 480 DLIVGSFGVD 490 KAVVYRGRPI 500 VSASASLSIF 510 PAMFNPEERS 520 CNLEGNPVAC 530 INLSFCLNAS 540 GKHVPDSIGF 550 TVELQLDWQK 560 QKGGVRRVLF 570 LASRQATLTQ 580 TLLIQNGARE 590 DCREMKIYLR 600 NESEFRDKLS 610 PIHIALNFSL 620 DPQAPVDSHG 630 LRPVLHYQSK 640 SRIEDKAQIL 650 LDCGEDNICV 660 PDLQLEVFGD 670 QNHVYLGDKN 680 SLNLTFHAQN 690 VGEGGAYEAE 700 LRVTAPPEAE 710 YSGLVRHPGN 720 FSSLSCDYFA 730 VNQSRLLVCD 740 LGNPMKAGAS 750 LWSGLRFTVP 760 HLRDTKKTIQ 770 FDFQILSKNL 780 NNSQSEVVSF 790 RLSVEAQAQV 800 SLNGVSKPEA 810 VIFPVSDWHP 820 RDPPQEEEDV 830 GPAVHHVYEL 840 INLGPSSISR 850 GVLELSCPQA 860 LEGRQLLYVT 870 RVTGLSNCTT 880 SHPLNPQGLE 890 LDPESPQHHR 900 LQRRDAASRS 910 PASSGPQILK 920 CPEAECFRLR 930 CELGPLHRQE 940 SRSLQLHFRV 950 WAKTFLQREH 960 QPFSLQCEAV 970 YQALKMPYRI 980 LPRQLPQKEL 990 QVATAVQWIK 1000 AEGSHGVPLW 1010 IIILAILVGL 1020 LLLGLLIYIL 1030 YKLGFFKRSL 1040 PYGTAMEKAQ LKPPATSDA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0008305 integrin complex
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0005102 signaling receptor binding
Biological Process GO:0033627 cell adhesion mediated by integrin
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0045765 regulation of angiogenesis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.