Overview
| Uniprot ID | A0A5G2QKU4 |
|---|
| Protein Name | - |
|---|
| Gene Name | COPS7A |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 107 |
SVVTLAAKVKCIPYA |
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively
Protein Sequence
10
MSAEVKVTGQ
20
NQEQFLLLAK
30
SAKGAALATL
40
IHQVLEAPGV
50
YVFGELLDMP
60
NVRELAESDF
70
ASTFRLLTVF
80
AYGTYADYLA
90
EARNLPPLTE
100
AQKNKLRHLS
110
VVTLAAKVKC
120
IPYAVLLEAL
130
ALRNVRQLED
140
LVIEAVYADV
150
LRGSLDQRNQ
160
RLEVDYSIGR
170
DIQRQDLSAI
180
ARTLQEWCVG
190
CEVVLSGIEE
200
QVSRANQHKE
210
QQLGLKQQIE
220
SEVANLKKTI
230
KVTTAAAAAA
240
TSQDPEQHLT
250
ELREPAPGTN
260
QERQDLVQVE
270
LKGLSVLPRM
280
WVLAACLPLR
290
SPQRAFLCPW
PADNLGS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Biological Process |
GO:0010387 |
COP9 signalosome assembly |
| Biological Process |
GO:0000338 |
protein deneddylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.